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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Rattus norvegicus (Rat)
Gene	Gabbr1
Synonym	Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 GPRC3A [ Show all ]
Disease	N/A for non-human GPCRs
Length	991
Amino acid sequence	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
UniProt	Q9Z0U4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2753
IUPHAR	240
DrugBank	N/A

Ligand

Name	Cgp 35348
Molecular formula	C8H20NO4P
IUPAC name	3-aminopropyl(diethoxymethyl)phosphinic acid
Molecular weight	225.225
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	-3.3
Synonyms	AKOS024456485 CGP 35348 hydrate J-004972 PDSP1_000410 UNII-87TI61875H 3-aminopropyl(diethoxymethyl)phosphinic acid Biomol-NT_000237 MFCD11045877 QIIVUOWTHWIXFO-UHFFFAOYSA-N (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate 87TI61875H C8H20NO4P DTXSID70154064 NCGC00025074-02 SR-01000597421-1 123690-79-9 B6654 Cgp-35348 L000168 PDSP2_000408 ZINC29330911 (3-Amino-propyl)-diethoxymethyl-phosphinic acid 3-aminopropyl-(diethoxymethyl)phosphinic acid BN0594 CHEMBL40157 MolPort-003-983-819 SCHEMBL195698 (S)-(3-Aminopropyl)(Diethoxymethyl)phosphinic Acid AC1L32KY GTPL1069 P-(3-Aminopropyl)-P-diethoxymethylphosphinic acid Tocris-1245 2BW BDBM50033003 CGP35348 LS-172577 Phosphinic acid, (3-aminopropyl)(diethoxymethyl)- (3-aminopropyl)(diethoxymethyl)phosphinic acid BPBio1_000508 D04KMO NCGC00025074-01 SR-01000597421 [ Show all ]
Inchi Key	QIIVUOWTHWIXFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
PubChem CID	107699
ChEMBL	CHEMBL40157
IUPHAR	1069
BindingDB	50033003
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	15848.9 - 25118.9 nM	PMID9069281, PMID7650685	IUPHAR
IC50	27000.0 nM	PMID7650685	BindingDB,ChEMBL

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