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GPCR

NameGamma-aminobutyric acid type B receptor subunit 1
SpeciesRattus norvegicus (Rat)
GeneGabbr1
SynonymGb1
gamma-aminobutyric acid (GABA) B receptor 1
gamma-aminobutyric acid (GABA) B receptor
GABABR1
GABAB1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length991
Amino acid sequenceMLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
UniProtQ9Z0U4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2753
IUPHAR240
DrugBankN/A

Ligand

NameSCHEMBL6352033
Molecular formulaC10H16NO3P
IUPAC name3-aminopropyl-[hydroxy(phenyl)methyl]phosphinic acid
Molecular weight229.216
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP-3.0
SynonymsCGP-46165A
Inchi KeyQQRKQWHTJAJGJJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H16NO3P/c11-7-4-8-15(13,14)10(12)9-5-2-1-3-6-9/h1-3,5-6,10,12H,4,7-8,11H2,(H,13,14)
PubChem CID10059688
ChEMBLCHEMBL419582
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC508000.0 nMPMID7650685ChEMBL

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