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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Rattus norvegicus (Rat)
Gene	Gabbr1
Synonym	Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 GPRC3A [ Show all ]
Disease	N/A for non-human GPCRs
Length	991
Amino acid sequence	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
UniProt	Q9Z0U4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2753
IUPHAR	240
DrugBank	N/A

Ligand

Name	clonazepam
Molecular formula	C15H10ClN3O3
IUPAC name	5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
Molecular weight	315.713
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.4
Synonyms	Clonazepamum DEA No. 2737 1622-61-3 HMS2093H22 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one Kenoket 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one LS-34260 7-nitro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepin-2-one Paxam AN-49558 Ro 4-8180 BRN 0759557 SBI-0206863.P001 Chlonazepam ZINC3813003 Clonazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Clonopin DivK1c_000973 2H-1, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro- I14-1364 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Klonopin Rapidly Disintegrating 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one NINDS_000973 AB01563349_01 Rivatril Apetryl Ro 5-4023/B-7 CC-25924 Solfidin Clonazepam (JP15/USP/INN) Clonazepam [USAN:INN:BAN:JAN] D0CP4E 1,4.benzodiazepin-2-one FT-0603203 2H-1,4-Benzodiazepin-2-one, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro- Jsp003251 5-(2-chlorophenyl)-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one Lonazep 5PE9FDE8GB NSC179913 AKOS015902192 Rivotril BDBM50019213 Ro-54023 UNII-5PE9FDE8GB Clonazepam 1.0 mg/ml in Methanol Clonazepam, powder Clonazepamum [INN-Latin] DF2374250 2-H-1, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro- HMS503C07 5-(2-Chlorophenyl)-1,4-benzodiazepin-2-one Klonopin 5-(o-Chlorophenyl)-1,4-benzodiazepin-2-one Melzap 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one Ravotril Antelepsin Ro 4023 C-19452 SCHEMBL38899 Cloazepam Clonazepam solution, drug standard, 1.0 mg/mL in methanol CTK4A4881 1,3-Dihydro-5-(o-chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one DTXSID1022845 2H-1, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro- IDI1_000973 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one # Landsen 5-24-04-00351 (Beilstein Handbook Reference) NSC 179913 AC-15733 Rivatril (TN) BAS 00308658 Ro 54023 CCG-213669 SR-01000937610 Clonazepam (JP17/USP/INN) Clonazepam [USAN:USP:INN:BAN:JAN] clonazepam--dea schedule iv item DB01068 106955-87-7 GTPL6963 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one KBio1_000973 5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one LS-34156 622C613 Oprea1_168772 Alti-Clonazepam Rivotril (TN) BIDD:PXR0144 RO4023 CHEMBL452 WLN: T67 GMV JN IHJ CNW KR BG Clonazepam fine granules (JP17) Clonex DGBIGWXXNGSACT-UHFFFAOYSA-N 2-H-1,4-Benzodiazepin-2-one, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro- HSDB 3265 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one Klonopin (TN) 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one MLS003899214 A810362 Ravotril (TN) Antilepsin Ro 5-4023 C15H10ClN3O3 SMR000058982 Clonazepam tablets (JP17) D00280 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one EINECS 216-596-2 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro- Iktorivil 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one Lktorivil NSC-179913 AC1L1EI2 Rivoril BC209470 Ro-5-4023 CHEBI:3756 SR-01000937610-2 Clonazepam 0.1 mg/ml in Methanol Clonazepam, European Pharmacopoeia (EP) Reference Standard [ Show all ]
Inchi Key	DGBIGWXXNGSACT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
PubChem CID	2802
ChEMBL	CHEMBL452
IUPHAR	N/A
BindingDB	50019213
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.75 nM	PMID1848629	BindingDB
Ki	1.0 nM	PMID1848629	BindingDB
Ki	1.2 nM	PMID1848629	BindingDB
Ki	50.0 nM	PMID1848629	BindingDB

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