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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Rattus norvegicus (Rat)
Gene	Gabbr1
Synonym	Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 GPRC3A [ Show all ]
Disease	N/A for non-human GPCRs
Length	991
Amino acid sequence	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
UniProt	Q9Z0U4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2753
IUPHAR	240
DrugBank	N/A

Ligand

Name	(R)-Baclofen
Molecular formula	C10H12ClNO2
IUPAC name	(3R)-4-amino-3-(4-chlorophenyl)butanoic acid
Molecular weight	213.661
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-1.0
Synonyms	Benzeneporopanoic acid, (beta-(aminomethyl)-4-chloro-, (betaR)- d-Baclofen GTPL1064 LS-182284 R-(-)-Baclofen ST24035487 (betaR)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid W-5262 (\|AR)-\|A-(Aminomethyl)-4-chlorobenzenepropanoic Acid AB01566870_01 ANW-73016 Arbaclofen (USAN) C21605 D0W4PJ I04-1358 MolPort-002-507-841 s3072 STX209 (R)-4-amino-3-(4-chlorophenyl)butan-oic acid 2C0 AGI-006 B5102 CS-13178 DTXSID90219366 KS-00000LLT p-chlorophenyl GABA SR-01000597441-1 (-)-Baclofen UNII-H789N3FKE8 component KPYSYYIEGFHWSV-QMMMGPOBSA-N (R)-4-Amino-3-(4-chlorophenyl)butyric Acid 69308-37-8 AKOS015893035 API0000916 Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, (R)- D03ZYQ GTPL3428 M03BX01 R-Baclofen STX 209 (R)-(-)-Baclofen ZINC61 0687AC AC-22385 Arbaclofen [USAN:INN] CHEMBL301742 KB-63255 NCGC00024796-01 SCHEMBL351220 TC-161761 (R)-4-Amino-3-(4-chlorophenyl)butanoic acid 308A378 AJ-07845 BDBM50032964 CTK8C4757 FT-0662468 l-Baclofen PubChem18285 ST079288 (3R)-4-amino-3-(4-chlorophenyl)butanoic acid UNII-NYU6UTW25B A9172 AN-37917 Arbaclofen BG0394 D09791 HY-17354 MCULE-5448996279 R-Baclofen RS STX-209 (R)-4-Amino-3-(4-chloro-phenyl)-butyric acid [3H](R)-(-)-baclofen AC1L2C6G AX8047687 CS-0889 DB08891 KPYSYYIEGFHWSV-QMMMGPOBSA-N NYU6UTW25B SR-01000597441 Tocris-0796 (R)-4-Amino-3-(4-chlorophenyl)butanoicacid 4-Amino-3-(4-chloro-phenyl)-butyric acid AK109161 [ Show all ]
Inchi Key	KPYSYYIEGFHWSV-QMMMGPOBSA-N
Inchi ID	InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1
PubChem CID	44602
ChEMBL	N/A
IUPHAR	1064
BindingDB	N/A
DrugBank	DB08891
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	25118.9 - 39810.7 nM	PMID9069281	IUPHAR

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