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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Rattus norvegicus (Rat)
Gene	Gabbr1
Synonym	Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 GPRC3A [ Show all ]
Disease	N/A for non-human GPCRs
Length	991
Amino acid sequence	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
UniProt	Q9Z0U4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2753
IUPHAR	240
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	HMS503A15 Plidan Jinpanfan Q-Pam Relanium LA 111 Reliver Lizan Mentalium Diazetard MLS001424086 Domalium NCGC00260007-01 Duksen Nixtensyn Euphorin P NSC-77518 FT-0632135 Paranten Chuansuan Valitran 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one DB00829 Vazen 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Diapam Wy 3467 Alboral Diatran Ansiolin S.A.R.L. Diazepam 0.1 mg/ml in Methanol Armonil Serenack Diazepam Nordic BCP23002 Simasedan Diazepam, United States Pharmacopeia (USP) Reference Standard BIDD:GT0105 Stesolid Calmaven Tox21_202458 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CCG-100997 Trazepam 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Paxel HY-17027 Pomin KBio3_002780 Quiatril La-Iii Ro 5-2807 Mandro Diazepamum Methyldiazepinone Dipaz NC00247 DSSTox_CID_406 Nervium DZP Novazam Faustal Oprea1_126223 Gradual CS-0653 Valium R 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Desloneg Vival AAOVKJBEBIDNHE-UHFFFAOYSA-N Diaquel Zepaxid Amiprol Diazemuls Anxicalm SCHEMBL21442 Diazepam Desitin Atensine Servizepam Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Bensedin Solis Diazepam-ratiopharm Britazepam T-quil (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Calmod Tranqdyn 5-24-04-00300 (Beilstein Handbook Reference) Cercine Unisedil 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine HMS2051N04 Placidox 2 IDI1_000967 Psychopax Kratium Relaminal Levium MCULE-8990989144 Diazepan leo Metil Gobanal DivK1c_000967 NCGC00178168-03 DTXSID4020406 NINDS_000967 Elcion CR NSC 169897 Freudal Pacitran Valeo 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one D07JVL Vanconin 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Dialag Winii AC1L1EZE Diastat Acudial Anlin S.A. R.L Diazepam (intranasal, epilepsy) Apo-diazepam Seduksen Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Baogin Sibazone Diazepam [USAN:USP:INN:BAN:JAN] Betapam Spectrum4_000576 C-17931 Tox21_113071 11100-37-1 Caudel Tranquo-puren 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Horizon Plumiaz Kabivitrum Q3JTX2Q7TU LA III Renborin Lovium Metamidol Dienpax Mono (2-ethylhexyl) phthalate Doval Nellium Dupin Noan Eurosan NSC169897 Gewacalm Parzam Condition Valium 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on DEA No. 2765 Vazepam A3662/0155188 Diapax WY-3467 Aliseum Diazapam Ansiolisina SAM001246536 Diazepam 1.0 mg/ml in Methanol Arzepam Serenamin Diazepam Rectubes BCP9000199 Sipam Diazepam-Eurogenerics BIDD:PXR0158 Stesolin Calmocitene Tranimul CCRIS 6009 Umbrium 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Paxum I06-0194 Pro pam KBioGR_001012 Quievita Lamra Ro-52807 Mandro-Zep Diazepamum [INN-Latin] Methyldiazepinone (pharmaceutical) Dipezona NCGC00178168-01 DSSTox_GSID_20406 neurolytr il e-Pam Novo-Dipam Faustan Ortopsique GTPL3364 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one D-Pam Valrelease 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Diacepan Vivol AB02310 Diastat ZINC6427 AN-23449 Diazemulus Anxionil Sedapam Diazepam Elmu Atilen Setonil Diazepam Stada Benzopin Sonacon Diazepamu BRN 0754371 Tensium 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Calmpose Tranquase Ceregulart Usempax ap HMS3393N04 Placidox 5 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 Relanium Liberetas Medipam Diazepin MLS000759402 Dizac NCGC00178168-04 Ducene Nivalen Eridan NSC-169897 Frustan Paralium Valiquid 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one D0Y1YC Vatran 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Dialar WLN: T67 GNV JN IHJ CG G1 KR AKOS003367969 Diastat, Valium Ansilive S.a. r.l. Diazepam (JP17/USP/INN) Apozepam Seduxen Diazepam Intensol BCP0726000176 Sico Relax Diazepam, European Pharmacopoeia (EP) Reference Standard Bialzepam Spectrum5_001890 C06948 Tox21_113071_1 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CC-26451 Tranquo-tablinen 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one CHEMBL12 Paxate HSDB 3057 Pms-Diazepam KBio1_000967 Quetinil LA-111 Ro 5-2805 LS-122 Methyl diazepinone Dipam Morosan Drenian Nerozen Duxen Notense Evacalm NSC77518 Gihitan CPD000058398 Valium (TN) 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Desconet Velium A826456 Diapine ZB000640 Alupram Diazem Antenex Saromet Diazepam Dak Assival Serenzin Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material BDBM50000766 SMR000058398 Diazepam-Lipuro BRD-K16508793-001-01-8 STK735517 Calmociteno Trankinon 439-14-5 Centrazepam UNII-Q3JTX2Q7TU 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Placidox 10 Iazepam Prozepam Kiatrium Radizepam Lembrol Ruhsitus Mandrozep Diazepan Methyldiazepinone, pharmaceutical Disopam NCGC00178168-02 DSSTox_RID_75566 Neurolytril EINECS 207-122-5 Novodipam Faustan, Paceum Gubex 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one D00293 Valuzepam 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diaceplex W-5055 AC-10561 Diastat (TN) Zipan An-Ding Apaurin Sedipam Diazepam Fabra Azedipamin Sibazon Diazepam [USAN:INN:BAN:JAN] Best [Pharaceutical] Spectrum3_001780 Diazepamu [Polish] BSPBio_003279 Tensopam 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one CAS-439-14-5 Tranquirit 53320-84-6 CHEBI:49575 Valaxona [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	18.0 nM	PMID1848629	BindingDB
Ki	19.0 nM	PMID1848629	BindingDB
Ki	20.0 nM	PMID1848629	BindingDB
Ki	22.0 nM	PMID1848629	BindingDB
Ki	26.0 nM	PMID1848629	BindingDB

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