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Name | Lysophosphatidic acid receptor 5 |
---|---|
Species | Homo sapiens (Human) |
Gene | LPAR5 |
Synonym | G-protein coupled receptor 92 LPAR5 LPA5 receptor LPA-5 LPA receptor 5 [ Show all ] |
Disease | N/A |
Length | 372 |
Amino acid sequence | MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL |
UniProt | Q9H1C0 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H1C0 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H1C0. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5700 |
IUPHAR | 124 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
535973 | CHEMBL3943469 | C24H20F3NO4 | 443.422 | 7 / 1 | 5.1 | No |
4542 | AC1LP5VO | C19H14N2O7 | 382.328 | 7 / 1 | 1.9 | Yes |
536052 | CHEMBL3920547 | C30H27NO4 | 465.549 | 4 / 1 | 6.2 | No |
536167 | CHEMBL3935519 | C30H24F3NO4 | 519.52 | 7 / 1 | 6.8 | No |
553283 | Farnesyl monophosphate | C15H27O4P | 302.351 | 4 / 2 | 3.7 | Yes |
536194 | CHEMBL3960586 | C27H26FNO4 | 447.506 | 5 / 1 | 6.0 | No |
14861 | 4-[5-(3-nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]butanoic acid | C18H14N2O7 | 370.317 | 7 / 1 | 2.1 | Yes |
536422 | CHEMBL3985179 | C25H24N2O5 | 432.476 | 6 / 1 | 3.9 | Yes |
17533 | CHEMBL357053 | C22H45O6PS | 468.63 | 7 / 2 | 8.4 | No |
17540 | CHEMBL153043 | C22H45O6PS | 468.63 | 7 / 2 | 8.4 | No |
17547 | CHEMBL2017139 | C22H45O6PS | 468.63 | 7 / 2 | 8.4 | No |
536534 | CHEMBL3900559 | C29H24FNO5 | 485.511 | 6 / 1 | 5.5 | No |
536613 | CHEMBL3942927 | C23H20ClNO4 | 409.866 | 4 / 1 | 4.9 | Yes |
536640 | CHEMBL3900867 | C25H21F2NO4 | 437.443 | 6 / 1 | 4.9 | Yes |
536667 | CHEMBL3956413 | C31H28FNO4 | 497.566 | 5 / 1 | 6.7 | No |
27910 | TC LPA5 4 | C23H23ClN2O3 | 410.898 | 4 / 1 | 6.5 | No |
29832 | LPA2 antagonist 1 | C20H23Cl2N5O2S2 | 500.457 | 8 / 1 | 4.3 | No |
537151 | CHEMBL3948456 | C25H24FNO4 | 421.468 | 5 / 1 | 5.4 | No |
537379 | CHEMBL3901720 | C24H20F3NO5 | 459.421 | 8 / 1 | 5.0 | Yes |
537747 | CHEMBL3961807 | C27H27NO4 | 429.516 | 4 / 1 | 5.6 | No |
537837 | CHEMBL3980736 | C31H26FNO4 | 495.55 | 5 / 1 | 6.2 | No |
537956 | CHEMBL3957378 | C29H24ClNO4 | 485.964 | 4 / 1 | 6.5 | No |
538059 | CHEMBL3908939 | C24H23NO4 | 389.451 | 4 / 1 | 4.7 | Yes |
538074 | CHEMBL3903990 | C26H23ClFNO4 | 467.921 | 5 / 1 | 6.1 | No |
538115 | CHEMBL3971670 | C30H27NO4 | 465.549 | 4 / 1 | 6.3 | No |
92819 | CHEMBL606354 | C23H15N3O6 | 429.388 | 6 / 1 | 2.8 | Yes |
538319 | CHEMBL3933338 | C26H24FNO4 | 433.479 | 5 / 1 | 4.7 | Yes |
538361 | CHEMBL3921376 | C26H24FNO5 | 449.478 | 6 / 1 | 4.7 | Yes |
538580 | CHEMBL3893992 | C26H23F2NO4 | 451.47 | 6 / 1 | 5.6 | No |
538600 | CHEMBL3892760 | C25H23F2NO5 | 455.458 | 7 / 1 | 4.9 | Yes |
538730 | CHEMBL3961765 | C25H25NO5 | 419.477 | 5 / 1 | 4.8 | Yes |
113881 | CHEMBL604677 | C21H12N2O7 | 404.334 | 7 / 1 | 3.3 | Yes |
538929 | CHEMBL3971635 | C25H21ClFNO4 | 453.894 | 5 / 1 | 5.4 | No |
561205 | SCHEMBL16506802 | C30H26FNO5 | 499.538 | 6 / 2 | 5.4 | No |
539128 | CHEMBL3955284 | C30H26FNO5 | 499.538 | 6 / 2 | 5.4 | No |
539159 | CHEMBL3939578 | C29H24FNO4 | 469.512 | 5 / 1 | 6.0 | No |
539300 | CHEMBL3959098 | C23H17F4NO4 | 447.386 | 8 / 1 | 5.1 | No |
132753 | AC1LRAEE | C20H13N3O5 | 375.34 | 6 / 0 | 2.7 | Yes |
539338 | CHEMBL3972525 | C24H21FN2O4 | 420.44 | 6 / 1 | 4.0 | Yes |
539564 | CHEMBL3920905 | C29H24FNO4 | 469.512 | 5 / 1 | 5.5 | No |
539730 | CHEMBL3911605 | C29H24FNO5 | 485.511 | 6 / 1 | 5.5 | No |
540123 | CHEMBL3976680 | C26H24FNO4 | 433.479 | 5 / 1 | 5.3 | No |
162857 | CHEMBL2335048 | C22H47O5PS | 454.647 | 6 / 2 | 8.8 | No |
162864 | CHEMBL2335047 | C22H47O5PS | 454.647 | 6 / 2 | 8.8 | No |
162869 | CHEMBL2335052 | C22H47O5PS | 454.647 | 6 / 2 | 8.8 | No |
163621 | CHEMBL2335050 | C21H44NaO5PS | 462.602 | 6 / 1 | N/A | N/A |
540210 | CHEMBL3963121 | C23H18F3NO4 | 429.395 | 7 / 1 | 4.9 | Yes |
540223 | CHEMBL3910049 | C26H24FNO5 | 449.478 | 6 / 1 | 4.7 | Yes |
178096 | CHEMBL2335051 | C22H44NaO6PS | 490.612 | 7 / 1 | N/A | N/A |
540740 | CHEMBL3986752 | C25H22FNO4 | 419.452 | 5 / 1 | 4.8 | Yes |
540921 | CHEMBL3985727 | C25H24FNO5 | 437.467 | 6 / 1 | 4.9 | Yes |
540925 | CHEMBL3923068 | C24H23NO5 | 405.45 | 5 / 1 | 4.3 | Yes |
190299 | Ki16425 | C23H23ClN2O5S | 474.956 | 7 / 2 | 4.5 | Yes |
486635 | AM095 free acid | C27H24N2O5 | 456.498 | 6 / 2 | 5.0 | Yes |
541282 | CHEMBL3891142 | C27H26FNO5 | 463.505 | 6 / 1 | 4.7 | Yes |
541364 | CHEMBL3934403 | C30H27NO5 | 481.548 | 5 / 1 | 5.9 | No |
541617 | CHEMBL3979729 | C29H24ClNO4 | 485.964 | 4 / 1 | 6.5 | No |
541873 | CHEMBL3987061 | C25H22F3NO5 | 473.448 | 8 / 1 | 5.4 | No |
542000 | CHEMBL3947618 | C28H28FNO4 | 461.533 | 5 / 1 | 5.2 | No |
542082 | CHEMBL3948271 | C23H18ClF2NO4 | 445.847 | 6 / 1 | 5.4 | No |
542127 | CHEMBL3933337 | C23H17ClF3NO4 | 463.837 | 7 / 1 | 5.7 | No |
233026 | 2-[5-(4-nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]benzoic acid | C21H12N2O7 | 404.334 | 7 / 1 | 3.3 | Yes |
542496 | CHEMBL3927774 | C27H27NO5 | 445.515 | 5 / 1 | 5.0 | Yes |
542499 | CHEMBL3966386 | C26H24FNO4 | 433.479 | 5 / 1 | 5.1 | No |
542600 | CHEMBL3942192 | C26H27NO5 | 433.504 | 5 / 1 | 5.2 | No |
542640 | CHEMBL3893864 | C30H27NO5 | 481.548 | 5 / 1 | 5.9 | No |
542717 | CHEMBL3896384 | C24H19F4NO4 | 461.413 | 8 / 1 | 5.5 | No |
543280 | CHEMBL3910281 | C28H21F2NO4 | 473.476 | 6 / 1 | 5.6 | No |
278359 | CHEMBL2335050 | C21H44O5PS- | 439.612 | 6 / 1 | 8.2 | No |
543536 | CHEMBL3920849 | C27H29NO5 | 447.531 | 5 / 0 | 5.5 | No |
543708 | CHEMBL3951978 | C25H22ClNO4 | 435.904 | 4 / 1 | 5.3 | No |
543744 | CHEMBL3914963 | C28H21ClFNO4 | 489.927 | 5 / 1 | 6.2 | No |
290483 | CHEMBL2335049 | C20H42NaO5PS | 448.575 | 6 / 1 | N/A | N/A |
544318 | CHEMBL3918970 | C26H24FNO5 | 449.478 | 6 / 1 | 4.7 | Yes |
544356 | CHEMBL3891550 | C28H22FNO4 | 455.485 | 5 / 1 | 5.5 | No |
310816 | AC1LR8M9 | C22H14N2O7 | 418.361 | 7 / 1 | 3.7 | Yes |
544433 | CHEMBL3973570 | C23H20FNO4 | 393.414 | 5 / 1 | 4.4 | Yes |
544449 | CHEMBL3897650 | C24H23N3O5 | 433.464 | 7 / 1 | 3.3 | Yes |
544591 | CHEMBL3975980 | C24H22FNO4 | 407.441 | 5 / 1 | 4.9 | Yes |
544628 | CHEMBL3948718 | C27H26FNO4 | 447.506 | 5 / 1 | 5.3 | No |
544644 | CHEMBL3942894 | C29H25NO4 | 451.522 | 4 / 1 | 5.8 | No |
544761 | CHEMBL3915509 | C25H24FNO4 | 421.468 | 5 / 1 | 5.3 | No |
544767 | CHEMBL3936755 | C31H29NO5 | 495.575 | 5 / 1 | 6.2 | No |
544897 | CHEMBL3907299 | C23H20FN3O4 | 421.428 | 7 / 1 | 3.4 | Yes |
544964 | CHEMBL3908908 | C31H34FNO5 | 519.613 | 6 / 1 | 6.0 | No |
544991 | CHEMBL3945517 | C26H25NO5 | 431.488 | 5 / 1 | 4.6 | Yes |
545090 | CHEMBL3920145 | C29H23F2NO5 | 503.502 | 7 / 1 | 5.6 | No |
545245 | CHEMBL3943133 | C30H25F2NO4 | 501.53 | 6 / 1 | 6.4 | No |
545266 | CHEMBL3918468 | C28H21F2NO4 | 473.476 | 6 / 1 | 5.6 | No |
356924 | CHEMBL2335051 | C22H44O6PS- | 467.622 | 7 / 1 | 8.3 | No |
555124 | 2-cis,6-cis-farnesyl diphosphate | C15H28O7P2 | 382.33 | 7 / 3 | 2.6 | Yes |
545913 | CHEMBL3935056 | C23H23N3O5 | 421.453 | 7 / 1 | 3.4 | Yes |
546222 | CHEMBL3966526 | C31H28FNO5 | 513.565 | 6 / 1 | 6.3 | No |
380358 | 1-Oleoyl Lysophosphatidic Acid | C21H41O7P | 436.526 | 7 / 3 | 5.2 | No |
555175 | lysophosphatidic acid | C21H41O7P | 436.526 | 7 / 3 | 5.2 | No |
546272 | CHEMBL3959515 | C29H22N2O4 | 462.505 | 5 / 1 | 5.1 | No |
385037 | STK010162 | C22H12N2O9 | 448.343 | 9 / 2 | 2.9 | Yes |
546504 | CHEMBL3890476 | C26H26FNO4 | 435.495 | 5 / 1 | 5.7 | No |
395587 | CHEMBL610179 | C16H10N2O7 | 342.263 | 7 / 1 | 1.9 | Yes |
546769 | CHEMBL3911962 | C31H29NO4 | 479.576 | 4 / 1 | 6.6 | No |
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