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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 5
Species	Homo sapiens (Human)
Gene	LPAR5
Synonym	G-protein coupled receptor 92 LPAR5 LPA5 receptor LPA-5 LPA receptor 5 G protein-coupled receptor 92 GPR92 G-protein coupled receptor 93 GPR93 [ Show all ]
Disease	N/A
Length	372
Amino acid sequence	MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
UniProt	Q9H1C0
Protein Data Bank	N/A
GPCR-HGmod model	Q9H1C0
3D structure model	This predicted structure model is from GPCR-EXP Q9H1C0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5700
IUPHAR	124
DrugBank	N/A

Ligand

Name	CHEMBL3891142
Molecular formula	C27H26FNO5
IUPAC name	4-[[[4-(2-fluorophenoxy)benzoyl]-[(3-methoxycyclobutyl)methyl]amino]methyl]benzoic acid
Molecular weight	463.505
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.7
Synonyms	US9464060, 7 BDBM251671 SCHEMBL16506487
Inchi Key	MEBSTCAWUQVIOV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H26FNO5/c1-33-23-14-19(15-23)17-29(16-18-6-8-21(9-7-18)27(31)32)26(30)20-10-12-22(13-11-20)34-25-5-3-2-4-24(25)28/h2-13,19,23H,14-17H2,1H3,(H,31,32)
PubChem CID	117902924
ChEMBL	CHEMBL3891142
IUPHAR	N/A
BindingDB	251671
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	31.0 nM	, None	BindingDB,ChEMBL

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