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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 5
Species	Homo sapiens (Human)
Gene	LPAR5
Synonym	G-protein coupled receptor 92 LPAR5 LPA5 receptor LPA-5 LPA receptor 5 G protein-coupled receptor 92 GPR92 G-protein coupled receptor 93 GPR93 [ Show all ]
Disease	N/A
Length	372
Amino acid sequence	MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
UniProt	Q9H1C0
Protein Data Bank	N/A
GPCR-HGmod model	Q9H1C0
3D structure model	This predicted structure model is from GPCR-EXP Q9H1C0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5700
IUPHAR	124
DrugBank	N/A

Ligand

Name	STK010162
Molecular formula	C22H12N2O9
IUPAC name	5-[5-(3-nitrophenoxy)-1,3-dioxoisoindol-2-yl]benzene-1,3-dicarboxylic acid
Molecular weight	448.343
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	2.9
Synonyms	5-[5-(3-nitrophenoxy)-1,3-dioxoisoindol-2-yl]benzene-1,3-dicarboxylic acid SMSF0005081 AKOS000638328 DTXSID10367954 5-[5-(3-nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]benzene-1,3-dicarboxylic acid CB13747 Oprea1_228597 5233-13-6 CHEMBL603414 BAS 00332794 MCULE-7915730516 5-[5-(3-nitrophenoxy)-1,3-dioxo-isoindol-2-yl]benzene-1,3-dicarboxylic acid CBMicro_014889 Oprea1_583433 AC1M4E64 CTK1H0404 ZINC3144209 5-[5-(3-Nitro-phenoxy)-1,3-dioxo-1,3-dihydro-isoindol-2-yl]-isophthalic acid BIM-0014746.P001 MolPort-001-024-867 [ Show all ]
Inchi Key	WXVRJSMFWYUKFE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H12N2O9/c25-19-17-5-4-16(33-15-3-1-2-13(9-15)24(31)32)10-18(17)20(26)23(19)14-7-11(21(27)28)6-12(8-14)22(29)30/h1-10H,(H,27,28)(H,29,30)
PubChem CID	2306021
ChEMBL	CHEMBL603414
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	43.0 %	PMID19800804	ChEMBL

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