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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 5
Species	Homo sapiens (Human)
Gene	LPAR5
Synonym	G-protein coupled receptor 92 LPAR5 LPA5 receptor LPA-5 LPA receptor 5 G protein-coupled receptor 92 GPR92 G-protein coupled receptor 93 GPR93 [ Show all ]
Disease	N/A
Length	372
Amino acid sequence	MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
UniProt	Q9H1C0
Protein Data Bank	N/A
GPCR-HGmod model	Q9H1C0
3D structure model	This predicted structure model is from GPCR-EXP Q9H1C0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5700
IUPHAR	124
DrugBank	N/A

Ligand

Name	CHEMBL3921376
Molecular formula	C26H24FNO5
IUPAC name	4-[[cyclopropylmethyl-[4-(5-fluoro-2-methoxyphenoxy)benzoyl]amino]methyl]benzoic acid
Molecular weight	449.478
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.7
Synonyms	US9464060, 79 BDBM251743 SCHEMBL16507258
Inchi Key	GGHASMDNUJBHLO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H24FNO5/c1-32-23-13-10-21(27)14-24(23)33-22-11-8-19(9-12-22)25(29)28(15-17-2-3-17)16-18-4-6-20(7-5-18)26(30)31/h4-14,17H,2-3,15-16H2,1H3,(H,30,31)
PubChem CID	117903528
ChEMBL	CHEMBL3921376
IUPHAR	N/A
BindingDB	251743
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	68.0 nM	, None	BindingDB,ChEMBL

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