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Name | Glucose-dependent insulinotropic receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Gpr119 |
Synonym | G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 468 |
Amino acid sequence | MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG |
UniProt | Q7TQN8 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5262 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
441712 | CHEMBL3326687 | C22H24F2N6O6S | 538.527 | 13 / 0 | 2.4 | No |
5711 | CHEMBL1773288 | C23H29N5O5S | 487.575 | 8 / 0 | 3.2 | Yes |
6164 | CHEMBL1775177 | C22H28N6O5S | 488.563 | 9 / 0 | 1.9 | Yes |
10216 | CHEMBL1775175 | C22H25N5O6S | 487.531 | 9 / 0 | 1.9 | Yes |
11415 | CHEMBL1951033 | C22H31N5O6S | 493.579 | 10 / 1 | 2.9 | Yes |
442204 | CHEMBL3325849 | C19H22F2N4O6S | 472.464 | 11 / 0 | 2.7 | No |
14295 | CHEMBL1951015 | C20H27N5O3 | 385.468 | 7 / 1 | 3.3 | Yes |
16830 | CHEMBL1773292 | C22H26FN5O6S | 507.537 | 9 / 1 | 2.0 | No |
17599 | CHEMBL1775170 | C20H23N5O5S | 445.494 | 8 / 0 | 2.2 | Yes |
442681 | CHEMBL3325850 | C20H24F2N4O6S | 486.491 | 11 / 0 | 2.6 | No |
442682 | CHEMBL3325851 | C20H24F2N4O6S | 486.491 | 11 / 0 | 2.6 | No |
442835 | CHEMBL3326689 | C21H20ClFN6O5S | 522.936 | 11 / 0 | 2.3 | No |
32719 | CHEMBL1951022 | C21H29N5O5S | 463.553 | 9 / 1 | 2.9 | Yes |
32816 | CHEMBL1773290 | C22H27N5O5S | 473.548 | 8 / 0 | 2.7 | Yes |
443058 | CHEMBL3326685 | C22H25FN6O6S | 520.536 | 12 / 0 | 2.8 | No |
40231 | CHEMBL1951012 | C21H27FN4O5S | 466.528 | 9 / 1 | 3.3 | Yes |
443304 | CHEMBL3326673 | C21H27FN4O5S2 | 498.588 | 10 / 0 | 3.4 | Yes |
53085 | CHEMBL1949674 | C21H28N4O4 | 400.479 | 7 / 0 | 3.7 | Yes |
54122 | CHEMBL1775173 | C22H27N5O5S | 473.548 | 8 / 0 | 3.2 | Yes |
443890 | CHEMBL3325846 | C21H24F4N4O6S | 536.499 | 13 / 0 | 3.6 | No |
59099 | 733750-99-7 | C21H24FN7O5S | 505.525 | 12 / 1 | 3.9 | No |
60260 | CHEMBL1775174 | C23H27N5O5S | 485.559 | 8 / 0 | 3.1 | Yes |
444084 | CHEMBL3326672 | C20H25FN4O5S2 | 484.561 | 10 / 0 | 3.2 | Yes |
69336 | CHEMBL1773287 | C23H28FN5O4S | 489.566 | 8 / 0 | 3.1 | Yes |
76068 | CHEMBL1775178 | C22H26FN5O5S | 491.538 | 9 / 0 | 2.9 | Yes |
76204 | CHEMBL1951011 | C21H26FN3O6S | 467.512 | 9 / 0 | 3.3 | Yes |
90442 | CHEMBL1951025 | C21H29N5O5S | 463.553 | 9 / 1 | 2.9 | Yes |
445414 | CHEMBL3326680 | C19H21F3N4O5S | 474.455 | 11 / 0 | 2.5 | No |
445816 | CHEMBL3326674 | C20H23FN4O5S2 | 482.545 | 10 / 0 | 2.9 | Yes |
112854 | CHEMBL1951028 | C22H31N5O5S | 477.58 | 9 / 1 | 3.3 | Yes |
446310 | CHEMBL3325461 | C20H24F2N4O5S | 470.492 | 10 / 0 | 2.4 | Yes |
124197 | CHEMBL1773294 | C21H24N4O6S | 460.505 | 9 / 0 | 2.5 | Yes |
446686 | CHEMBL3325844 | C21H27FN4O6S | 482.527 | 10 / 0 | 2.8 | Yes |
131417 | CHEMBL1951021 | C21H28N4O6S | 464.537 | 9 / 0 | 2.9 | Yes |
447188 | CHEMBL3326669 | C20H23FN4O7S | 482.483 | 11 / 0 | 1.5 | No |
447271 | CHEMBL3326676 | C21H25FN4O5S2 | 496.572 | 10 / 0 | 3.3 | Yes |
143825 | CHEMBL1951016 | C19H25N5O3 | 371.441 | 7 / 1 | 2.9 | Yes |
447414 | CHEMBL3325843 | C20H25FN4O6S | 468.5 | 10 / 0 | 2.6 | Yes |
148838 | CHEMBL1773289 | C24H31N5O5S | 501.602 | 8 / 0 | 3.6 | No |
448050 | CHEMBL3326681 | C20H23F3N4O5S | 488.482 | 11 / 0 | 3.0 | No |
163313 | CHEMBL1773293 | C22H26N4O6S | 474.532 | 9 / 0 | 2.7 | Yes |
448113 | CHEMBL3325847 | C21H24FN5O6S | 493.51 | 11 / 0 | 2.2 | No |
448140 | CHEMBL3326678 | C21H25FN4O5S2 | 496.572 | 10 / 0 | 3.2 | Yes |
176125 | CHEMBL1773283 | C22H26FN5O4S2 | 507.599 | 9 / 0 | 3.5 | No |
179224 | CHEMBL1951013 | C21H29N5O5S | 463.553 | 9 / 1 | 2.9 | Yes |
448946 | CHEMBL3325852 | C20H22F4N4O6S | 522.472 | 13 / 0 | 3.4 | No |
448949 | CHEMBL3326666 | C20H22F4N4O6S | 522.472 | 13 / 0 | 3.4 | No |
187695 | CHEMBL1773286 | C23H29N5O4S | 471.576 | 7 / 0 | 3.0 | Yes |
198441 | CHEMBL1951019 | C20H23N5O4 | 397.435 | 8 / 0 | 2.6 | Yes |
199906 | CHEMBL1775169 | C22H27N5O5S | 473.548 | 8 / 0 | 2.8 | Yes |
217225 | CHEMBL1951020 | C21H28N4O5 | 416.478 | 8 / 0 | 3.6 | Yes |
220130 | CHEMBL1773285 | C22H27N5O6S2 | 521.607 | 9 / 0 | 2.1 | No |
230198 | CHEMBL1775172 | C22H27N5O5S | 473.548 | 8 / 0 | 3.1 | Yes |
237014 | CHEMBL1773277 | C22H28N6O4S | 472.564 | 8 / 1 | 2.8 | Yes |
451326 | CHEMBL3326677 | C20H25FN4O5S2 | 484.561 | 10 / 0 | 3.2 | Yes |
252753 | CHEMBL1951024 | C21H28N4O6S | 464.537 | 9 / 0 | 2.9 | Yes |
452135 | CHEMBL3326671 | C21H22F4N4O7S | 550.482 | 14 / 0 | 2.5 | No |
452139 | CHEMBL3326675 | C21H25FN4O5S2 | 496.572 | 10 / 0 | 3.1 | Yes |
269670 | CHEMBL1949688 | C19H24N6O7S | 480.496 | 11 / 1 | 2.9 | No |
452624 | CHEMBL3326668 | C22H27FN4O6S | 494.538 | 10 / 0 | 3.1 | Yes |
282210 | CHEMBL1773279 | C24H32N6O4S | 500.618 | 8 / 0 | 3.2 | No |
290606 | CHEMBL1775176 | C23H29N5O5S | 487.575 | 8 / 0 | 3.6 | Yes |
293256 | CHEMBL1766082 | C22H28N4O5 | 428.489 | 8 / 0 | 2.7 | Yes |
453436 | CHEMBL3326688 | C23H25FN6O5S | 516.548 | 11 / 0 | 2.5 | No |
300883 | CHEMBL1773291 | C21H26N6O5S | 474.536 | 9 / 0 | 2.4 | Yes |
312873 | CHEMBL1951017 | C20H26N4O4 | 386.452 | 7 / 0 | 3.3 | Yes |
454723 | CHEMBL3325842 | C20H26FN5O5S | 467.516 | 10 / 1 | 2.6 | Yes |
454753 | CHEMBL3325848 | C21H26F2N4O6S | 500.518 | 11 / 0 | 2.8 | No |
328719 | CHEMBL1773282 | C22H27N5O4S2 | 489.609 | 8 / 0 | 3.4 | Yes |
454854 | CHEMBL3326667 | C21H25FN4O6S | 480.511 | 10 / 0 | 2.6 | Yes |
455390 | CHEMBL3326682 | C21H24F2N4O5S | 482.503 | 10 / 0 | 2.5 | Yes |
345438 | CHEMBL1773281 | C24H31FN6O4S | 518.608 | 9 / 0 | 3.5 | No |
357323 | CHEMBL1773280 | C25H34N6O4S | 514.645 | 8 / 0 | 3.5 | No |
362837 | CHEMBL1951014 | C21H29N5O5S | 463.553 | 9 / 1 | 2.9 | Yes |
371007 | CHEMBL1951023 | C20H27N5O5S | 449.526 | 9 / 1 | 2.5 | Yes |
456470 | CHEMBL3325845 | C21H25FN4O6S | 480.511 | 10 / 0 | 2.7 | Yes |
376808 | CHEMBL1775171 | C21H25N5O5S | 459.521 | 8 / 0 | 2.6 | Yes |
378924 | APD597 | C21H29N5O6S | 479.552 | 10 / 1 | 2.5 | Yes |
456971 | CHEMBL3326670 | C22H24F4N4O6S | 548.51 | 13 / 0 | 3.7 | No |
457066 | CHEMBL3326686 | C22H24F2N6O6S | 538.527 | 13 / 0 | 2.4 | No |
391101 | CHEMBL1773284 | C22H27N5O5S2 | 505.608 | 9 / 0 | 1.9 | No |
400657 | APD668 | C21H24FN5O5S | 477.511 | 9 / 0 | 2.7 | Yes |
457744 | CHEMBL3326683 | C22H27FN4O5S | 478.539 | 9 / 0 | 3.0 | Yes |
410299 | CHEMBL1766081 | C20H26N4O4 | 386.452 | 7 / 0 | 3.3 | Yes |
458582 | CHEMBL3326679 | C18H18F4N4O5S | 478.419 | 12 / 0 | 2.5 | No |
431265 | CHEMBL1773278 | C23H30N6O4S | 486.591 | 8 / 1 | 3.0 | Yes |
432538 | CHEMBL3104879 | C23H19ClFN3O5S | 503.929 | 8 / 1 | 4.1 | No |
438030 | CHEMBL1951018 | C19H23FN4O4 | 390.415 | 8 / 0 | 3.0 | Yes |
438232 | CHEMBL1951026 | C20H26N4O4 | 386.452 | 7 / 0 | 3.3 | Yes |
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