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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	APD597
Molecular formula	C21H29N5O6S
IUPAC name	propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate
Molecular weight	479.552
Hydrogen bond acceptor	10
Hydrogen bond donor	1
XlogP	2.5
Synonyms	CS-5278 JNJ 38431055 SCHEMBL386884 APD 597 DTXSID10237885 KB-146004 ZINC38256220 APD597(JNJ-38431055) HY-15566 propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate ADP-597 D0O9XN JNJ-38431055 UNII-345354O7AT 345354O7AT APD-597 EX-A1213 MolPort-042-665-884 BCP17733 CHEMBL1951032 isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate SB16860 AKOS026751481 DB12084 JNJ38431055 WPDCHTSXOPUOII-UHFFFAOYSA-N 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester BDBM50364559 GTPL5727 propan-2-yl 4-({6-[(6-methanesulfonyl-2-methylpyridin-3-yl)amino]-5-methoxypyrimidin-4-yl}oxy)piperidine-1-carboxylate 897732-93-3 [ Show all ]
Inchi Key	WPDCHTSXOPUOII-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
PubChem CID	11691484
ChEMBL	CHEMBL1951032
IUPHAR	5727
BindingDB	50364559
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
378924	Glucose-dependent insulinotropic receptor	Q7TQN8	Gpr119	Rattus norvegicus (Rat)	468
378925	Glucose-dependent insulinotropic receptor	Q8TDV5	GPR119	Homo sapiens (Human)	335

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