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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Rattus norvegicus (Rat)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	468
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
UniProt	Q7TQN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5262
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3326689
Molecular formula	C21H20ClFN6O5S
IUPAC name	(5-chloropyrimidin-2-yl)-[4-[5-fluoro-6-(2-methyl-6-methylsulfonylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidin-1-yl]methanone
Molecular weight	522.936
Hydrogen bond acceptor	11
Hydrogen bond donor	0
XlogP	2.3
Synonyms	BDBM50056104
Inchi Key	BPXJSGIERMPYKH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20ClFN6O5S/c1-12-15(3-4-16(28-12)35(2,31)32)34-20-17(23)19(26-11-27-20)33-14-5-7-29(8-6-14)21(30)18-24-9-13(22)10-25-18/h3-4,9-11,14H,5-8H2,1-2H3
PubChem CID	118711798
ChEMBL	CHEMBL3326689
IUPHAR	N/A
BindingDB	50056104
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	30.9 nM	PMID25088191	ChEMBL
EC50	31.0 nM	PMID25088191	BindingDB
Efficacy	77.0 %	PMID25088191	ChEMBL

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