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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Rattus norvegicus (Rat)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	468
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
UniProt	Q7TQN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5262
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1773290
Molecular formula	C22H27N5O5S
IUPAC name	tert-butyl 4-[9-(4-methylsulfonylphenyl)purin-6-yl]oxypiperidine-1-carboxylate
Molecular weight	473.548
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	2.7
Synonyms	143093-EP2287165A2 4-[9-(4-Methanesulfonyl-phenyl)-9H-purin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester tert-butyl 4-(9-(4-(methylsulfonyl)phenyl)-9H-purin-6-yloxy)piperidine-1-carboxylate BDBM50343461 143093-EP2287166A2 4-[9-(4-Methanesulfonyl-phenyl)9H-purin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester BTYRTNRWQFWQNI-UHFFFAOYSA-N 143093-EP2292620A2 SCHEMBL392033 [ Show all ]
Inchi Key	BTYRTNRWQFWQNI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27N5O5S/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)31-20-18-19(23-13-24-20)27(14-25-18)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
PubChem CID	53630423
ChEMBL	CHEMBL1773290
IUPHAR	N/A
BindingDB	50343461
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ratio EC50	3.0 -	PMID21444206	ChEMBL

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