Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Melanocyte-stimulating hormone receptor
Species	Mus musculus (Mouse)
Gene	Mc1r
Synonym	MC1 receptor MC1-R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Melanocortin receptor 1 MSH-R
Disease	N/A for non-human GPCRs
Length	315
Amino acid sequence	MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
UniProt	Q01727
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4077
IUPHAR	N/A
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
159	CHEMBL137344	C27H34N4O2S	478.655	4 / 3	3.8	Yes
242	CHEMBL75475	C25H40N6O3	472.634	4 / 3	1.1	Yes
463044	CHEMBL3577985	C51H66N12O9	991.164	10 / 9	1.0	No
3805	CHEMBL235798	C26H29N5O	427.552	2 / 3	3.3	Yes
5971	CHEMBL2369967	C70H85N17O16	1420.55	18 / 18	-2.5	No
5978	CHEMBL2096721	C70H85N17O16	1420.55	18 / 19	-2.2	No
8134	CHEMBL431523	C24H31N5O2	421.545	3 / 5	1.7	Yes
8176	CHEMBL445669	C41H51N3O4	649.876	5 / 3	7.7	No
8993	CHEMBL237070	C32H42FN3O	503.706	3 / 2	6.3	No
9773	CHEMBL237930	C29H31N3O	437.587	2 / 2	4.7	Yes
10923	BDBM50106532	C64H78N14O14S2	1331.53	18 / 17	-0.7	No
11091	CID 102096776	C71H90N20O15S3	1559.81	33 / 22	4.0	No
521796	CHEMBL3799563	C46H67N13O10	962.123	13 / 11	-1.4	No
12240	CHEMBL216295	C50H69N15O10	1040.2	13 / 13	0.3	No
12914	CHEMBL392094	C33H40ClN3O3	562.151	4 / 1	6.7	No
13886	CHEMBL344489	C34H43N9O5	657.776	7 / 8	0.7	No
15602	CHEMBL569696	C31H36F3N9O4	655.683	9 / 7	1.5	No
16258	CHEMBL104052	C33H42N12O5	686.778	8 / 9	-1.1	No
17737	CHEMBL338768	C32H35ClN4O4S	607.166	6 / 2	4.0	No
18259	CHEMBL410435	C33H29N3O2	499.614	2 / 1	5.9	No
522046	CHEMBL3799094	C74H101N23O16	1568.77	19 / 17	-3.2	No
22161	CHEMBL237052	C24H31N3O	377.532	2 / 2	3.8	Yes
23005	CHEMBL406891	C52H67N15O9S2	1110.32	14 / 14	-0.2	No
23944	CHEMBL125492	C34H40ClFN4O3	607.167	5 / 1	4.8	No
24644	CHEMBL396111	C41H52ClN3O4	686.334	5 / 3	8.4	No
26904	CHEMBL62228	C25H32N6O2	448.571	4 / 5	2.4	Yes
27696	CHEMBL394394	C39H48FN3O2	609.83	4 / 3	7.9	No
28882	CHEMBL224277	C53H73N15O11	1096.26	13 / 14	-0.5	No
31252	CHEMBL602654	C44H55N11O7	849.994	8 / 8	0.4	No
31830	CHEMBL237937	C22H22ClN3O2	395.887	3 / 2	3.4	Yes
33158	CHEMBL438672	C22H25N3O	347.462	2 / 2	2.9	Yes
467199	CHEMBL3577991	C51H66N12O9	991.164	10 / 9	1.0	No
35310	CID 44310242	C68H80N18O17	1421.5	21 / 20	-2.4	No
35315	BDBM50144874	C68H80N18O17	1421.5	21 / 21	-2.0	No
35335	CHEMBL236840	C33H36ClN3O3	558.119	4 / 1	6.7	No
35368	CHEMBL414900	C71H84N20O17	1489.58	22 / 22	-2.9	No
35372	CHEMBL2371699	C71H84N20O17	1489.58	22 / 21	-3.3	No
36344	CHEMBL270691	C27H21ClN2O2	440.927	2 / 1	5.7	No
467503	CHEMBL3578001	C78H103N21O19S2	1702.93	23 / 25	-0.9	No
37136	CHEMBL397550	C34H46ClN3O3	580.21	4 / 2	6.8	No
37850	CHEMBL392521	C27H29N3O	411.549	2 / 2	4.1	Yes
38152	CHEMBL238180	C22H25N3O	347.462	2 / 2	3.3	Yes
38693	CHEMBL428022	C23H26ClN3O	395.931	2 / 2	3.9	Yes
522721	CHEMBL3798421	C80H107N23O15	1630.88	19 / 21	0.4	No
39997	CHEMBL2304248	C107H152N28O27S2	2326.68	33 / 32	-6.4	No
39999	CHEMBL2304250	C107H152N28O27S2	2326.68	33 / 32	-6.4	No
40003	CHEMBL2304246	C107H152N28O27S2	2326.68	33 / 32	-6.4	No
40007	BDBM50422954	C107H152N28O27S2	2326.68	33 / 30	-7.1	No
40011	CHEMBL2369131	C107H152N28O27S2	2326.68	33 / 32	-6.4	No
40016	CHEMBL2304249	C107H152N28O27S2	2326.68	33 / 32	-6.4	No
443275	CHEMBL3350327	C107H152N28O27S2	2326.68	33 / 32	-6.4	No
443289	CHEMBL3422432	C41H46IN9O5	871.781	6 / 8	3.7	No
443295	CHEMBL3422433	C41H46IN9O5	871.781	6 / 8	3.7	No
41103	CHEMBL393557	C26H35N3O	405.586	2 / 2	4.7	Yes
41364	CHEMBL393359	C27H31N3O	413.565	2 / 2	4.6	Yes
44415	CHEMBL305559	C23H29N5O2	407.518	3 / 5	1.9	Yes
44418	CHEMBL64954	C23H29N5O2	407.518	3 / 5	1.9	Yes
468539	CHEMBL3577980	C76H96N16O17	1505.7	18 / 18	2.3	No
46075	CHEMBL2369973	C73H86IN19O16	1612.51	19 / 19	-2.1	No
46076	CHEMBL2096727	C73H86IN19O16	1612.51	19 / 20	-1.7	No
46608	CID 54576099	C111H167FN30O26	2356.74	37 / 28	-9.3	No
46896	CHEMBL2096722	C67H83N19O16	1410.52	19 / 20	-4.0	No
46900	CHEMBL2369968	C67H83N19O16	1410.52	19 / 19	-4.4	No
49205	CHEMBL236861	C34H44ClN3O	546.196	2 / 2	7.3	No
49619	CHEMBL138771	C37H45N9O5	695.825	6 / 7	1.2	No
50487	CHEMBL268395	C27H33N3O	415.581	2 / 2	4.6	Yes
469159	CHEMBL3577986	C54H66N12O9	1027.2	10 / 9	1.9	No
51101	CHEMBL235358	C33H43ClFN3O	552.175	3 / 2	7.4	No
523030	CHEMBL3798912	C50H69N13O10	1012.18	13 / 11	-0.2	No
51831	CHEMBL568577	C30H36ClN9O4	622.127	6 / 7	1.2	No
52137	CHEMBL305391	C24H31N5O2	421.545	3 / 5	2.3	Yes
52482	CHEMBL272439	C20H22ClN5O2	399.879	3 / 3	1.7	Yes
53551	CHEMBL191304	C49H73N11O5	896.195	7 / 9	7.9	No
469598	CHEMBL3577977	C84H114N22O21S2	1832.09	25 / 27	-2.5	No
54366	CHEMBL405335	C52H74N16O9	1067.27	12 / 13	-0.4	No
56083	CHEMBL448536	C35H42N12O5	710.8	8 / 9	-0.3	No
56813	CHEMBL394647	C21H28N2OS	356.528	3 / 1	3.9	Yes
56856	CHEMBL138100	C40H48N8O5	720.875	6 / 3	2.2	No
58382	CHEMBL433296	C34H43N11O5	685.79	7 / 9	-0.3	No
58393	Ac-His-Phe-Arg-DTrp-NH2	C34H43N11O5	685.79	7 / 9	-0.3	No
58400	Ac-His-Phe-Arg-Trp-NH2	C34H43N11O5	685.79	7 / 9	-0.3	No
58403	CHEMBL264190	C34H43N11O5	685.79	7 / 9	-0.3	No
58412	CHEMBL94391	C34H43N11O5	685.79	7 / 9	-0.3	No
58417	CHEMBL152612	C34H43N11O5	685.79	7 / 9	-0.3	No
58656	CHEMBL236630	C25H30ClN3O	423.985	2 / 2	4.6	Yes
58848	CHEMBL2096716	C67H84N18O16	1397.52	19 / 18	-3.8	No
58850	CHEMBL2369962	C67H84N18O16	1397.52	19 / 17	-4.2	No
444087	CHEMBL3358537	C51H69N17O8	1048.22	12 / 12	2.5	No
60682	CHEMBL396655	C22H27N3O	349.478	2 / 2	3.1	Yes
63207	CHEMBL566760	C32H37N9O5	627.706	7 / 8	1.1	No
64603	CHEMBL565900	C31H36N10O5	628.694	8 / 8	0.2	No
64654	CHEMBL138212	C35H45N11O5	699.817	7 / 8	0.1	No
470886	CHEMBL3577994	C54H66N12O9	1027.2	10 / 9	1.9	No
470930	CHEMBL3577998	C51H68N12O8	977.181	10 / 9	1.6	No
65154	CHEMBL607103	C35H43N11O5	697.801	7 / 8	-0.2	No
65159	CHEMBL607104	C35H43N11O5	697.801	7 / 8	-0.2	No
65160	BDBM50115367	C35H43N11O5	697.801	7 / 8	-0.2	No
65903	CHEMBL1688108	C39H50N12O6S	814.967	9 / 9	0.0	No
65980	CHEMBL429451	C35H49N3O3	559.795	4 / 2	6.6	No
66078	CHEMBL370261	C46H67N11O5	854.114	7 / 9	6.2	No

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417