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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanocyte-stimulating hormone receptor
Species	Mus musculus (Mouse)
Gene	Mc1r
Synonym	MC1 receptor MC1-R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Melanocortin receptor 1 MSH-R
Disease	N/A for non-human GPCRs
Length	315
Amino acid sequence	MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
UniProt	Q01727
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4077
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3358537
Molecular formula	C51H69N17O8
IUPAC name	(2S)-2-[[(2S)-2-acetamidohexanoyl]amino]-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxopent-4-yn-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-6-azidohexanamide
Molecular weight	1048.22
Hydrogen bond acceptor	12
Hydrogen bond donor	12
XlogP	2.5
Synonyms	BDBM50031494
Inchi Key	DIDFXWFVHNRNMN-PMHRFVFWSA-N
Inchi ID	InChI=1S/C51H69N17O8/c1-4-6-19-38(61-31(3)69)45(71)63-39(21-12-13-24-60-68-55)46(72)67-43(27-34-29-56-30-59-34)50(76)65-41(25-32-16-8-7-9-17-32)48(74)64-40(22-14-23-57-51(53)54)47(73)66-42(49(75)62-37(15-5-2)44(52)70)26-33-28-58-36-20-11-10-18-35(33)36/h2,7-11,16-18,20,28-30,37-43,58H,4,6,12-15,19,21-27H2,1,3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,71)(H,64,74)(H,65,76)(H,66,73)(H,67,72)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1
PubChem CID	118722928
ChEMBL	CHEMBL3358537
IUPHAR	N/A
BindingDB	50031494
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.24 nM	PMID25347033	ChEMBL
EC50	0.24 nM	PMID25347033	BindingDB

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