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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Ac-His-Phe-Arg-Trp-NH2
Molecular formula	C34H43N11O5
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular weight	685.79
Hydrogen bond acceptor	7
Hydrogen bond donor	9
XlogP	-0.3
Synonyms	110392-38-6 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2) CHEMBL50056 Ac-His-DPhe-Arg-Trp-NH2 L-Tryptophanamide, N-acetyl-L-histidyl-L-phenylalanyl-L-arginyl- 2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2 BDBM50034910 CTK0D4815 (S)-2-{(S)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide Ac-His-Phe-Arg-Trp-NH(2) 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide Ac-His-D-Phe-Arg-D-Trp-NH2 D0U5KM [ Show all ]
Inchi Key	DFCJPPDAOZROBS-DZUOILHNSA-N
Inchi ID	InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1
PubChem CID	10484741
ChEMBL	CHEMBL50056
IUPHAR	N/A
BindingDB	50034910
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
58398	Melanocortin receptor 3	P41968	MC3R	Homo sapiens (Human)	323
58401	Melanocortin receptor 3	P33033	Mc3r	Mus musculus (Mouse)	323
58396	Melanocortin receptor 4	P32245	MC4R	Homo sapiens (Human)	332
58399	Melanocortin receptor 4	P56450	Mc4r	Mus musculus (Mouse)	332
58397	Melanocortin receptor 5	P41149	Mc5r	Mus musculus (Mouse)	325
58395	Melanocyte-stimulating hormone receptor	Q01726	MC1R	Homo sapiens (Human)	317
58400	Melanocyte-stimulating hormone receptor	Q01727	Mc1r	Mus musculus (Mouse)	315

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