You can:
| Name | Vasopressin V1b receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | AVPR1B |
| Synonym | AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 [ Show all ] |
| Disease | Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder |
| Length | 424 |
| Amino acid sequence | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF |
| UniProt | P47901 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P47901 |
| 3D structure model | This predicted structure model is from GPCR-EXP P47901. |
| BioLiP | N/A |
| Therapeutic Target Database | T59881 |
| ChEMBL | CHEMBL1921 |
| IUPHAR | 367 |
| DrugBank | BE0000773 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 211 |  BAS 04995413 | C23H27N5O4 | 437.5 | 6 / 2 | 0.7 | Yes |
| 214 |  3,6-dichloro-1-benzothiophene-2-carboxylic acid | C9H4Cl2O2S | 247.089 | 3 / 1 | 4.1 | Yes |
| 288 |  ethyl 6-(5-{[(8-bromo-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl}-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate | C22H23BrN6O4S | 547.428 | 8 / 2 | 2.0 | No |
| 297 |  BAS 00662566 | C8H12N4O3S | 244.269 | 5 / 3 | 0.2 | Yes |
| 451 |  MLS000686201 | C17H18N6O2S | 370.431 | 7 / 1 | 1.0 | Yes |
| 1148 |  868968-75-6 | C20H18N6O3S | 422.463 | 8 / 1 | 2.0 | Yes |
| 1347 |  2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-(2-morpholinoethyl)acetamide | C20H21N3O4 | 367.405 | 5 / 1 | 1.2 | Yes |
| 535955 |  SCHEMBL15987890 | C26H31ClN4O2 | 467.01 | 4 / 1 | 4.1 | Yes |
| 2905 |  AC1N8RBE | C19H21N5O5S2 | 463.527 | 9 / 1 | 1.7 | Yes |
| 3138 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 3352 |  CHEMBL1643598 | C20H27N3O4S2 | 437.573 | 7 / 1 | 3.4 | Yes |
| 4644 |  CHEMBL1779411 | C32H30ClN3O6S | 620.117 | 8 / 0 | 5.6 | No |
| 5333 |  AC1NLL93 | C16H16ClN3O5S | 397.83 | 7 / 1 | 1.7 | Yes |
| 536097 |  SCHEMBL15987910 | C27H35N5O4 | 493.608 | 6 / 1 | 3.0 | Yes |
| 6244 |  CHEMBL1643587 | C28H37N3O3S2 | 527.742 | 7 / 1 | 5.6 | No |
| 6828 |  SMR000363287 | C17H19ClN2O7S2 | 462.916 | 8 / 0 | 3.2 | Yes |
| 7192 |  AC1MQQCV | C21H23N5O6S | 473.504 | 8 / 1 | 1.9 | Yes |
| 536157 |  SCHEMBL15988159 | C26H31ClFN5O2 | 500.015 | 5 / 1 | 4.7 | No |
| 7453 |  CHEMBL1221422 | C24H30ClN5O3 | 471.986 | 5 / 1 | 3.5 | Yes |
| 7735 |  CHEMBL1790720 | C61H72N12O18S2 | 1325.43 | 21 / 15 | -0.9 | No |
| 536183 |  SCHEMBL15987951 | C26H33N5O3 | 463.582 | 6 / 1 | 2.4 | Yes |
| 8227 |  MLS001029173 | C24H31N7O3S | 497.618 | 8 / 2 | 1.9 | Yes |
| 557512 |  SCHEMBL15987859 | C27H33ClN6O2 | 509.051 | 6 / 1 | 3.9 | No |
| 557517 |  2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N'-[(E)-(4-hydroxy-3-methoxyphenyl)methylidene]acetohydrazide | C17H18N6O5 | 386.368 | 7 / 2 | 0.2 | Yes |
| 9380 |  CHEMBL1817690 | C44H69N13O12S2 | 1036.23 | 16 / 11 | -3.5 | No |
| 9522 |  BAS 09528148 | C10H14N2O2S | 226.294 | 4 / 1 | 1.9 | Yes |
| 10058 |  Phenypressin | C46H65N15O11S2 | 1068.24 | 15 / 13 | -4.5 | No |
| 10946 |  AC1ORZTA | C15H18N4O5S | 366.392 | 6 / 2 | -1.0 | Yes |
| 11110 |  CHEMBL1778934 | C32H34N4O2 | 506.65 | 4 / 1 | 4.9 | No |
| 11409 |  852168-54-8 | C15H17N7O3S2 | 407.467 | 9 / 1 | 1.2 | Yes |
| 13377 |  CHEMBL1779415 | C29H27ClN4O7S | 611.066 | 10 / 0 | 4.0 | No |
| 13555 |  MLS002154012 | C18H25N5NaO9P | 509.388 | 12 / 2 | N/A | No |
| 536354 |  SCHEMBL15987978 | C29H40N6O2 | 504.679 | 6 / 1 | 4.4 | No |
| 13914 |  CHEMBL489386 | C18H19ClN4O3 | 374.825 | 6 / 0 | 2.6 | Yes |
| 14449 |  SMR000046898 | C20H19N7O3S2 | 469.538 | 9 / 1 | 2.0 | Yes |
| 14501 |  CHEMBL1778939 | C30H30N4O2 | 478.596 | 4 / 1 | 4.2 | Yes |
| 14816 |  MLS001095782 | C22H25ClN6O3 | 456.931 | 7 / 1 | 1.8 | Yes |
| 536374 |  SCHEMBL15987924 | C28H36N4O3 | 476.621 | 5 / 1 | 3.9 | Yes |
| 15572 |  CHEMBL1779235 | C26H33N3O5S | 499.626 | 6 / 1 | 3.4 | Yes |
| 557752 |  SCHEMBL15987713 | C29H37N5O4 | 519.646 | 6 / 1 | 3.6 | No |
| 17319 |  AC1NB7KM | C18H21N3O6S2 | 439.501 | 8 / 1 | 0.4 | Yes |
| 536434 |  SCHEMBL15988088 | C25H30ClFN6O3 | 517.002 | 7 / 1 | 3.0 | No |
| 17409 |  CHEMBL583082 | C29H37N3O6S3 | 619.81 | 10 / 1 | 4.0 | No |
| 557771 |  SCHEMBL15988010 | C26H31ClN4O2 | 467.01 | 4 / 2 | 4.0 | Yes |
| 522002 |  CHEMBL3719005 | C20H14F3N3O2 | 385.346 | 6 / 2 | 4.0 | Yes |
| 17552 |  MLS000936813 | C20H22N6O4S2 | 474.554 | 8 / 2 | 1.0 | Yes |
| 522010 |  CHEMBL3715676 | C22H15F3N4O2 | 424.383 | 6 / 3 | 4.6 | Yes |
| 18172 |  CHEMBL1222760 | C23H28ClN5O2 | 441.96 | 4 / 1 | 2.7 | Yes |
| 18970 |  CHEMBL1779229 | C25H35N3O4S | 473.632 | 6 / 1 | 3.6 | Yes |
| 19034 |  MLS000936863 | C19H19N5O3S | 397.453 | 6 / 1 | 2.0 | Yes |
| 19336 |  CHEMBL1790713 | C73H85N11O19S2 | 1484.66 | 21 / 15 | 3.7 | No |
| 19346 |  5-[(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methyl]-N-isopropyl-2-methoxybenzenesulfonamide | C18H19N3O5S | 389.426 | 7 / 1 | 1.4 | Yes |
| 19390 |  CHEMBL1778946 | C29H28N4O2 | 464.569 | 4 / 1 | 4.0 | Yes |
| 19710 |  N-(5-chloro-2-methylphenyl)-4-(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)butanamide | C18H16ClN3O3 | 357.794 | 4 / 1 | 2.3 | Yes |
| 20712 |  MLS001116560 | C21H19N3O6S | 441.458 | 8 / 1 | 1.6 | Yes |
| 442488 |  CHEMBL3354586 | C46H73N11O12S | 1004.22 | 13 / 11 | -0.2 | No |
| 21739 |  Terlipressin | C52H74N16O15S2 | 1227.38 | 19 / 16 | -5.8 | No |
| 465576 |  CHEMBL3186564 | C23H28ClN3O2 | 413.946 | 3 / 0 | 4.6 | Yes |
| 557963 |  SCHEMBL15987669 | C29H35FN4O3 | 506.622 | 6 / 1 | 4.2 | No |
| 22128 |  AC1M7NVA | C16H16N4O3 | 312.329 | 5 / 0 | 0.7 | Yes |
| 22622 |  MLS002180522 | C19H21ClN2O4S | 408.897 | 5 / 1 | 3.9 | Yes |
| 23728 |  CHEMBL2172288 | C66H63N9O12S | 1206.34 | 15 / 7 | 4.8 | No |
| 23881 |  1-methyl-4-oxo-1,4-dihydropyrido[1,2-a]pyrrolo[2,3-d]pyrimidine-2-carboxylic acid | C12H9N3O3 | 243.222 | 4 / 1 | 0.5 | Yes |
| 442623 |  CHEMBL3354600 | C46H67N11O12S2 | 1030.23 | 14 / 11 | -0.8 | No |
| 536612 |  SCHEMBL15988031 | C26H31ClN4O3 | 483.009 | 4 / 1 | 3.4 | Yes |
| 24854 |  2-Chloroadenosine | C10H12ClN5O4 | 301.687 | 8 / 4 | -0.1 | Yes |
| 553384 |  Lysipressin | C46H65N13O12S2 | 1056.22 | 16 / 13 | -3.9 | No |
| 25318 |  CHEMBL1819552 | C39H67N13O11S2 | 958.165 | 15 / 12 | -4.4 | No |
| 25351 |  CHEMBL1779406 | C34H39ClN4O6S | 667.218 | 8 / 0 | 4.7 | No |
| 26131 |  MLS001116669 | C21H23N3O5S | 429.491 | 7 / 0 | 2.1 | Yes |
| 27360 |  MLS001030387 | C21H23N3O5S | 429.491 | 7 / 1 | 2.4 | Yes |
| 27851 |  CHEMBL1222761 | C25H32ClN5O2 | 470.014 | 4 / 1 | 3.5 | Yes |
| 29840 |  CHEMBL572754 | C30H43N3O7S2 | 621.808 | 10 / 1 | 3.4 | No |
| 30003 |  CHEMBL2369845 | C46H65N13O11S2 | 1040.23 | 14 / 12 | -2.0 | No |
| 30006 |  CHEMBL411013 | C46H65N13O11S2 | 1040.23 | 14 / 12 | -2.0 | No |
| 30657 |  AC1LCZ0G | C12H10Br2N2OS | 390.093 | 3 / 1 | 3.8 | Yes |
| 536763 |  SCHEMBL15987869 | C26H33FN6O4 | 512.586 | 8 / 1 | 2.4 | No |
| 558227 |  BDBM175032 | C36H43N5O6S | 673.829 | 10 / 0 | 3.5 | No |
| 31670 |  CHEMBL1224608 | C24H27N5O4 | 449.511 | 6 / 3 | 1.0 | Yes |
| 31821 |  CHEMBL1819541 | C42H65N13O12S2 | 1008.18 | 16 / 13 | -4.5 | No |
| 31993 |  MLS002279973 | C13H16KN5O7S | 425.457 | 11 / 1 | N/A | No |
| 33056 |  memantine | C12H21N | 179.307 | 1 / 1 | 3.3 | Yes |
| 33264 |  MLS000624310 | C16H17N5O2S | 343.405 | 7 / 0 | 2.4 | Yes |
| 443030 |  CHEMBL3354598 | C49H71N11O12S | 1038.23 | 13 / 11 | 0.0 | No |
| 34745 |  CHEMBL575359 | C27H30ClN3O3S2 | 544.125 | 6 / 1 | 4.5 | No |
| 34886 |  CHEMBL1778945 | C30H32N4O2 | 480.612 | 4 / 1 | 4.5 | Yes |
| 34958 |  MLS001116679 | C21H23N3O5S | 429.491 | 7 / 0 | 2.1 | Yes |
| 35127 |  Cyclic AMP sodium | C10H11N5NaO6P | 351.191 | 10 / 2 | N/A | N/A |
| 35882 |  CHEMBL1817698 | C44H69N13O12S2 | 1036.23 | 16 / 13 | -4.4 | No |
| 35973 |  pentoxifylline | C13H18N4O3 | 278.312 | 4 / 0 | 0.3 | Yes |
| 36000 |  CHEMBL576147 | C27H31ClN4O3S2 | 559.14 | 6 / 2 | 4.4 | No |
| 36546 |  CHEMBL1684553 | C25H30N4O5 | 466.538 | 7 / 1 | 1.8 | Yes |
| 36895 |  MLS000419234 | C20H13FN2O3 | 348.333 | 5 / 1 | 3.6 | Yes |
| 522635 |  CHEMBL3718178 | C20H14F3N3O2 | 385.346 | 6 / 2 | 4.0 | Yes |
| 536948 |  SCHEMBL15987882 | C26H30F3N5O3 | 517.553 | 8 / 1 | 3.7 | No |
| 536965 |  SCHEMBL15987900 | C27H34ClN5O2 | 496.052 | 4 / 1 | 5.1 | No |
| 38475 |  CHEMBL1779419 | C31H31ClN4O6S | 623.121 | 9 / 1 | 4.1 | No |
| 38728 |  ethyl 1-[(4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidin-2-yl)carbonyl]piperidine-4-carboxylate | C19H19N3O4S | 385.438 | 6 / 0 | 2.1 | Yes |
| 39080 |  AC1MLIHO | C14H18Cl2N2O4S | 381.268 | 6 / 1 | 3.9 | Yes |
| 443247 |  CHEMBL3354599 | C49H71N11O11S | 1022.23 | 12 / 10 | 0.3 | No |
zhanglab
zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417