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GPCR

Name	Vasopressin V1b receptor
Species	Homo sapiens (Human)
Gene	AVPR1B
Synonym	AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 V1bR V1B receptor Antidiuretic hormone receptor 1b AVPR V1b AVPR V3 VPR3 [ Show all ]
Disease	Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder
Length	424
Amino acid sequence	MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProt	P47901
Protein Data Bank	N/A
GPCR-HGmod model	P47901
3D structure model	This predicted structure model is from GPCR-EXP P47901.
BioLiP	N/A
Therapeutic Target Database	T59881
ChEMBL	CHEMBL1921
IUPHAR	367
DrugBank	BE0000773

Ligand

Name	AC1ORZTA
Molecular formula	C15H18N4O5S
IUPAC name	N-[4-[(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)methylsulfamoyl]phenyl]acetamide
Molecular weight	366.392
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	-1.0
Synonyms	MCULE-6577851205 ZINC5488967 N-(4-(N-((1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl)sulfamoyl)phenyl)acetamide CHEMBL1494013 SMR000652123 MLS001158499 AKOS005542522 N-(4-{[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]sulfamoyl}phenyl)acetamide HMS2958G06 STK606630 904265-13-0 MolPort-002-662-853 N-[4-[(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)methylsulfamoyl]phenyl]acetamide [ Show all ]
Inchi Key	APGGNUNZWQEHQW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H18N4O5S/c1-10(20)17-11-4-6-13(7-5-11)25(23,24)16-9-12-8-14(21)19(3)15(22)18(12)2/h4-8,16H,9H2,1-3H3,(H,17,20)
PubChem CID	7711621
ChEMBL	CHEMBL1494013
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	30881.0 nM	PubChem BioAssay data set	ChEMBL

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