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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V1b receptor
Species	Homo sapiens (Human)
Gene	AVPR1B
Synonym	AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 V1bR V1B receptor Antidiuretic hormone receptor 1b AVPR V1b AVPR V3 VPR3 [ Show all ]
Disease	Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder
Length	424
Amino acid sequence	MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProt	P47901
Protein Data Bank	N/A
GPCR-HGmod model	P47901
3D structure model	This predicted structure model is from GPCR-EXP P47901.
BioLiP	N/A
Therapeutic Target Database	T59881
ChEMBL	CHEMBL1921
IUPHAR	367
DrugBank	BE0000773

Ligand

Name	SCHEMBL15988010
Molecular formula	C26H31ClN4O2
IUPAC name	2-[2-(3-chlorophenyl)-4-[4-[2-(3-hydroxypyrrolidin-1-yl)ethyl]phenyl]imidazol-1-yl]-N-propan-2-ylacetamide
Molecular weight	467.01
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.0
Synonyms	US9522914, A-06
Inchi Key	AYGFZMCREYAFRE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H31ClN4O2/c1-18(2)28-25(33)17-31-16-24(29-26(31)21-4-3-5-22(27)14-21)20-8-6-19(7-9-20)10-12-30-13-11-23(32)15-30/h3-9,14,16,18,23,32H,10-13,15,17H2,1-2H3,(H,28,33)
PubChem CID	90370548
ChEMBL	N/A
IUPHAR	N/A
BindingDB	260204
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	55.0 nM	N/A	BindingDB

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