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Name | Vasopressin V1b receptor |
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Species | Homo sapiens (Human) |
Gene | AVPR1B |
Synonym | AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 [ Show all ] |
Disease | Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder |
Length | 424 |
Amino acid sequence | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF |
UniProt | P47901 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47901 |
3D structure model | This predicted structure model is from GPCR-EXP P47901. |
BioLiP | N/A |
Therapeutic Target Database | T59881 |
ChEMBL | CHEMBL1921 |
IUPHAR | 367 |
DrugBank | BE0000773 |
Name | AC1MLIHO |
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Molecular formula | C14H18Cl2N2O4S |
IUPAC name | [3-methyl-1-oxo-1-(oxolan-2-ylmethylamino)butan-2-yl] 4,5-dichloro-1,2-thiazole-3-carboxylate |
Molecular weight | 381.268 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 3.9 |
Synonyms | SMR000601723 AKOS000738924 CHEMBL1581023 4,5-Dichloro-isothiazole-3-carboxylic acid 2-methyl-1-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-propyl ester [3-methyl-1-oxo-1-(oxolan-2-ylmethylamino)butan-2-yl] 4,5-dichloro-1,2-thiazole-3-carboxylate [ Show all ] |
Inchi Key | CCZMFGXGYJBMLG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H18Cl2N2O4S/c1-7(2)11(13(19)17-6-8-4-3-5-21-8)22-14(20)10-9(15)12(16)23-18-10/h7-8,11H,3-6H2,1-2H3,(H,17,19) |
PubChem CID | 3220371 |
ChEMBL | CHEMBL1581023 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Potency | 34649.1 nM | PubChem BioAssay data set | ChEMBL |
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