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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V1b receptor
Species	Homo sapiens (Human)
Gene	AVPR1B
Synonym	AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 V1bR V1B receptor Antidiuretic hormone receptor 1b AVPR V1b AVPR V3 VPR3 [ Show all ]
Disease	Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder
Length	424
Amino acid sequence	MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProt	P47901
Protein Data Bank	N/A
GPCR-HGmod model	P47901
3D structure model	This predicted structure model is from GPCR-EXP P47901.
BioLiP	N/A
Therapeutic Target Database	T59881
ChEMBL	CHEMBL1921
IUPHAR	367
DrugBank	BE0000773

Ligand

Name	SCHEMBL15988031
Molecular formula	C26H31ClN4O3
IUPAC name	2-[5-(3-chlorophenyl)-3-[4-(2-morpholin-4-ylethyl)phenyl]-2-oxoimidazol-1-yl]-N-propan-2-ylacetamide
Molecular weight	483.009
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.4
Synonyms	BDBM260308 US9522914, C-19
Inchi Key	BITVWYSHSJOCGC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H31ClN4O3/c1-19(2)28-25(32)18-31-24(21-4-3-5-22(27)16-21)17-30(26(31)33)23-8-6-20(7-9-23)10-11-29-12-14-34-15-13-29/h3-9,16-17,19H,10-15,18H2,1-2H3,(H,28,32)
PubChem CID	71555437
ChEMBL	N/A
IUPHAR	N/A
BindingDB	260308
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2.2 nM	N/A	BindingDB

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