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Name | Vasopressin V1b receptor |
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Species | Homo sapiens (Human) |
Gene | AVPR1B |
Synonym | AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 [ Show all ] |
Disease | Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder |
Length | 424 |
Amino acid sequence | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF |
UniProt | P47901 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47901 |
3D structure model | This predicted structure model is from GPCR-EXP P47901. |
BioLiP | N/A |
Therapeutic Target Database | T59881 |
ChEMBL | CHEMBL1921 |
IUPHAR | 367 |
DrugBank | BE0000773 |
Name | BDBM175032 |
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Molecular formula | C36H43N5O6S |
IUPAC name | 3-(5-ethoxy-2-methoxyphenyl)-1-(4-methoxyphenyl)sulfonyl-3-[6-(1-methylpiperidin-4-yl)-2,6-diazaspiro[3.3]heptan-2-yl]-2-oxo-3a,7a-dihydroindole-5-carbonitrile |
Molecular weight | 673.829 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 0 |
XlogP | 3.5 |
Synonyms | US9688678, 5 (+-)-3-(2-ethoxy-5-methoxy-phenyl)-1-(4-methoxyphenyl)sulfonyl-3-[2-(1-methyl-4-piperidyl)-2,6-diazaspiro[3.3]heptan-6-yl]-2-oxo-indoline-5-carbonitrile US9688678, 6 (−)-3-(2-ethoxy-5-methoxy-phenyl)-1-(4-methoxyphenyl)sulfonyl-3-[2-(1-methyl-4-piperidyl)-2,6-diazaspiro[3.3]heptan-6-yl]-2-oxo-indoline-5-carbonitrile |
Inchi Key | BRDNLIFRPRLLRN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C36H43N5O6S/c1-5-47-28-9-13-33(46-4)31(19-28)36(40-23-35(24-40)21-39(22-35)26-14-16-38(2)17-15-26)30-18-25(20-37)6-12-32(30)41(34(36)42)48(43,44)29-10-7-27(45-3)8-11-29/h6-13,18-19,26,30,32H,5,14-17,21-24H2,1-4H3 |
PubChem CID | 133081613 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 175032 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 5.5 nM | N/A | BindingDB |
Ki | 55.0 nM | N/A | BindingDB |
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