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Name | Vasopressin V1b receptor |
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Species | Homo sapiens (Human) |
Gene | AVPR1B |
Synonym | AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 [ Show all ] |
Disease | Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder |
Length | 424 |
Amino acid sequence | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF |
UniProt | P47901 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47901 |
3D structure model | This predicted structure model is from GPCR-EXP P47901. |
BioLiP | N/A |
Therapeutic Target Database | T59881 |
ChEMBL | CHEMBL1921 |
IUPHAR | 367 |
DrugBank | BE0000773 |
Name | CHEMBL1778934 |
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Molecular formula | C32H34N4O2 |
IUPAC name | N-(cyclopropylmethyl)-2-[4-oxo-2-phenyl-6-[4-(piperidin-1-ylmethyl)phenyl]quinazolin-3-yl]acetamide |
Molecular weight | 506.65 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.9 |
Synonyms | BDBM50345062 N-(cyclopropylmethyl)-2-(4-oxo-2-phenyl-6-(4-(piperidin-1-ylmethyl)phenyl)quinazolin-3(4H)-yl)acetamide SCHEMBL3552454 |
Inchi Key | APLNTDBKSIRJBX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C32H34N4O2/c37-30(33-20-23-9-10-23)22-36-31(26-7-3-1-4-8-26)34-29-16-15-27(19-28(29)32(36)38)25-13-11-24(12-14-25)21-35-17-5-2-6-18-35/h1,3-4,7-8,11-16,19,23H,2,5-6,9-10,17-18,20-22H2,(H,33,37) |
PubChem CID | 54585721 |
ChEMBL | CHEMBL1778934 |
IUPHAR | N/A |
BindingDB | 50345062 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
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IC50 | <20000.0 nM | PMID21596563 | BindingDB,ChEMBL |
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