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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V1b receptor
Species	Homo sapiens (Human)
Gene	AVPR1B
Synonym	AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 V1bR V1B receptor Antidiuretic hormone receptor 1b AVPR V1b AVPR V3 VPR3 [ Show all ]
Disease	Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder
Length	424
Amino acid sequence	MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProt	P47901
Protein Data Bank	N/A
GPCR-HGmod model	P47901
3D structure model	This predicted structure model is from GPCR-EXP P47901.
BioLiP	N/A
Therapeutic Target Database	T59881
ChEMBL	CHEMBL1921
IUPHAR	367
DrugBank	BE0000773

Ligand

Name	Cyclic AMP sodium
Molecular formula	C10H11N5NaO6P
IUPAC name	sodium;(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Molecular weight	351.191
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	None
Synonyms	MLS001333135 (4aR,6R,7R,7aS)-6-(6-Amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide, sodium salt Adenosine 3',5'-Cyclic Monophosphate Sodium Salt AKOS015916150 CTK8B3794 sodium 3',5'-cyclic amp anion 37839-81-9 Adenosine 3',5'-phosphoric acid sodium salt C10H11N5O6P.Na LS-15117 TR-030584 AC1Q1VCB Adenosine-3',5'-cyclic monophosphate sodium salt MLS001333136 3',5'-Amp sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate ANW-43203 Cyclic 3',5'-(hydrogen phosphate)adenosine monosodium salt HMS2231C17 sodium(4ar,6r,7r,7as)-6-(6-amino-9h-purin-9-yl)-7-hydroxytetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide 60-92-4 (Parent) Adenosine, cyclic 3',5'-(hydrogen phosphate)-, monosodium salt Camp sodium salt MFCD00069736 Adenosine 3',5'-cyclic monophosphate monosodium salt Adenosine-3',5'-Monophosphoric Acid CHEMBL1363683 SMR000875274 3',5'-Cyclic AMP sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate, >=98.0% (HPLC), powder c-AMP sodium salt Cyclic 3',5'-amp sodium salt I14-52594 ST24034754 6122AH Adenosine-3',5'-cyclic monophosphate monosodium salt cAMP-Na [ Show all ]
Inchi Key	BXJBFCKTIWRKMQ-MCDZGGTQSA-M
Inchi ID	InChI=1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
PubChem CID	23669773
ChEMBL	CHEMBL1363683
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	194.4 nM	PubChem BioAssay data set	ChEMBL

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