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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	U50488
Molecular formula	C19H26Cl2N2O
IUPAC name	2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
Molecular weight	369.33
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.4
Synonyms	BDBM50000296 GTPL1652 NIH 10533 U-50488 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]ethanamide 67198-13-4 CCG-205330 Lopac0_001256 trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamide U50,488H (+)-U-50488 A843453 CHEMBL441765 NCGC00016071-02 U 50488 UM 1382 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, trans- Lopac-U-110 SCHEMBL332193 U-50488H 83913-05-7 CHEBI:73358 LS-28505 trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide AC1MI0XE D0J1PJ NCGC00163181-01 U-50,488 ZINC643032 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide C11796 Lopac-U-111 trans-(+/-)-3,4-dichloro-n-methyl-n-(2-[1-pyrrolidinyl]cyclohexyl)benzeneacetamide U50,488 83913-06-8 NCGC00016071-01 U 50,488 U50488H 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]acetamide [ Show all ]
Inchi Key	VQLPLYSROCPWFF-QZTJIDSGSA-N
Inchi ID	InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
PubChem CID	3036289
ChEMBL	CHEMBL441765
IUPHAR	1652
BindingDB	50000296
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
361722	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
361729	Delta-type opioid receptor	P32300	Oprd1	Mus musculus (Mouse)	372
361731	Delta-type opioid receptor	P33533	Oprd1	Rattus norvegicus (Rat)	372
361723	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
361725	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
361727	Kappa-type opioid receptor	P33534	Oprk1	Mus musculus (Mouse)	380
361730	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
361724	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
361726	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
361728	Mu-type opioid receptor	P42866	Oprm1	Mus musculus (Mouse)	398
361733	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
361735	Mu-type opioid receptor	P79350	OPRM1	Bos taurus (Bovine)	401
361734	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
361732	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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