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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL418854
Molecular formula	C22H27ClN2O3
IUPAC name	N-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methyl]-1-[1-(2-methoxyphenyl)piperidin-4-yl]methanamine
Molecular weight	402.919
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.4
Synonyms	(7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(2-methoxy-phenyl)-piperidin-4-ylmethyl]-amine SCHEMBL6767394 BDBM50079939 D05IPO 170353-17-0 L018296 [ Show all ]
Inchi Key	QHLRKDSRGUZHSH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27ClN2O3/c1-26-20-5-3-2-4-19(20)25-10-8-16(9-11-25)13-24-14-18-15-27-21-7-6-17(23)12-22(21)28-18/h2-7,12,16,18,24H,8-11,13-15H2,1H3
PubChem CID	9865858
ChEMBL	CHEMBL418854
IUPHAR	N/A
BindingDB	50079939
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
278414	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
278415	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
278411	5-hydroxytryptamine receptor 1B	P79399	HTR1B	Sus scrofa (Pig)	150
278421	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
278424	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
278420	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436
278422	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448
278413	Alpha-2A adrenergic receptor	P22909	Adra2a	Rattus norvegicus (Rat)	450
278410	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
278423	D(1B) dopamine receptor	P21918	DRD5	Homo sapiens (Human)	477
278412	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
278417	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
278418	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
278416	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
278419	Histamine H1 receptor	P31390	Hrh1	Rattus norvegicus (Rat)	486

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