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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	DPDPE
Molecular formula	C30H39N5O7S2
IUPAC name	(4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
Molecular weight	645.79
Hydrogen bond acceptor	10
Hydrogen bond donor	7
XlogP	-0.6
Synonyms	Cyclic(D-penicillamine2,5)enkephalin D-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-, cyclic (2>5)-disulfide (9CI) Enkephalin, pen(2,5)- LS-161341 [D-Pen(2)-D-Pen(5)]-enkephaline (4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid Bis-penicillamine-enkephalin D-Penicillamine (2,5)-Enkephalin Dpdpe(SH)2 GTPL1608 SCHEMBL727022 [D-Pen2,5]-Enkephalin hydrate, >=95% (HPLC) (D-Pen2,D-Pen5)-Enkephalin 88381-29-7 Cyclic DPDPE D-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3- mercapto-, cyclic (2-5)-disulfide DPLPE H-Tyr-D-Pen-Gly-Phe-D-Pen-OH [2-D-Penicillamine, 5-D-penicillamine]enkephalin (4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid BDBM21008 cyclo-[D-Pen(2,5)]-enkephalin D0G4NM Enkephalin, penicillamine(2,5)- LY 198572 [D-Pen2, D-Pen5]enkephalin (4s,7s,13s)-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-13-(l-tyrosylamino)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid 88373-72-2 C20164 CHEMBL31421 D-penicillamine-(2,5)-enkephalin DPDPE-Cl H-Tyr-c(D-Pen-Gly-Phe-D-Pen)-OH Tyr-D-Pen-Gly-Phe-D-Pen [Disulfide Bridge: 2-5] [D-Pen2,5]Enkephalin 1,2-Dithia-5,8,11-triazacyclotetradecane, cyclic peptide deriv. AC1L2XHZ Cyclic [D-Pen2, D-Pen5]enkephalin D-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-, cyclic (2-5)-disulfide Enkephalin, D-penicillamine (2,5)- L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2-5)-disulfide [3H]DPDPE (4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3,3,14,14-tetramethyl-6,9,12-trioxo-7-(phenylmethyl)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid 2,5-Pen-enkephalin Bis-pen-enkephalin c[D-Pen(2,5)]-enkephalin Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) Pen(2),pen(5)-enkephalin [D-Pen2,5]-Enkephalin hydrate (D-Pen(2),D-pen(5))enkephalin 88373-73-3 CHEBI:73356 CTK8E0439 D-Valine, 3-mercapto-N-(N-(N-(3-mercapto-N-L-tyrosyl-D-valyl)glycyl)-L-phenylalanyl)- DPDPE-OH H-Tyr-cyclo-(D-Pen-Gly-Phe-D-Pen)-OH ZINC29206920 (4S,7S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid 1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid, 13-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3,3,14,14-tetramethyl-6,9,12-trioxo-7-(phenylmethyl)-, (4S,7S,13S)- AC1Q5JTC [ Show all ]
Inchi Key	MCMMCRYPQBNCPH-WMIMKTLMSA-N
Inchi ID	InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
PubChem CID	104787
ChEMBL	CHEMBL31421
IUPHAR	1608
BindingDB	21008
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
202152	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
202158	Delta-type opioid receptor	P33533	Oprd1	Rattus norvegicus (Rat)	372
202162	Delta-type opioid receptor	P32300	Oprd1	Mus musculus (Mouse)	372
461000	Delta-type opioid receptor	P79291	OPRD1	Sus scrofa (Pig)	228
202155	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
202157	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
202161	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
202153	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
202154	Mu-type opioid receptor	P42866	Oprm1	Mus musculus (Mouse)	398
202156	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
202160	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
202159	Neuropeptides B/W receptor type 1	P48145	NPBWR1	Homo sapiens (Human)	328

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