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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL299691
Molecular formula	C21H28FN3O2
IUPAC name	8-[2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight	373.472
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.9
Synonyms	8-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione BDBM50143674 CYDFRMLIERPUGG-UHFFFAOYSA-N 8-{2-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione SCHEMBL6751064
Inchi Key	CYDFRMLIERPUGG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H28FN3O2/c22-17-5-1-2-6-18(17)24-12-9-23(10-13-24)11-14-25-19(26)15-21(16-20(25)27)7-3-4-8-21/h1-2,5-6H,3-4,7-16H2
PubChem CID	9864325
ChEMBL	CHEMBL299691
IUPHAR	N/A
BindingDB	50143674
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
53382	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
53384	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
53387	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
53385	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
53381	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561
53388	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
53383	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
53386	D(3) dopamine receptor	P19020	Drd3	Rattus norvegicus (Rat)	446

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