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| Name | Beta-2 adrenergic receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | ADRB2 |
| Synonym | beta-2 adrenergic receptor Gpcr7 beta2-adrenoceptor Adrb-2 ADRB2R [ Show all ] |
| Disease | Premature labour Premature ejaculation Obesity Neurogenic bladder dysfunction Hypertension [ Show all ] |
| Length | 413 |
| Amino acid sequence | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL |
| UniProt | P07550 |
| Protein Data Bank | 3nya, 3ny9, 3ny8, 3d4s, 2rh1, 3pds, 4gbr, 4lde, 6mxt, 6csy, 5x7d, 5jqh, 5d6l, 5d5b, 5d5a, 4ldo, 4ldl, 4qkx |
| GPCR-HGmod model | P07550 |
| 3D structure model | This structure is from PDB ID 3nya. |
| BioLiP | BL0257082, BL0113951, BL0113950, BL0257084, BL0257085, BL0283869, BL0333729, BL0333730, BL0333731,BL0333732,BL0333733, BL0333734, BL0333735, BL0333736,BL0333737,BL0333738, BL0113952,BL0113953,BL0113954, BL0147310, BL0257081, BL0257080, BL0232997, BL0192129, BL0257083, BL0185746,BL0185747, BL0185745, BL0185743,BL0185744, BL0185742, BL0185740,BL0185741, BL0147311,BL0147312, BL0351701,BL0351703, BL0351702,BL0351704, BL0192128, BL0433200, BL0433199, BL0430930, BL0430929, BL0388810, BL0388809, BL0354449, BL0185748, BL0354450, BL0354451,BL0354452,BL0354453, BL0388807,BL0388808 |
| Therapeutic Target Database | T24555, T52522 |
| ChEMBL | CHEMBL210 |
| IUPHAR | 29 |
| DrugBank | BE0000694 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 208 |  MLS000392662 | C10H14ClN3S2 | 275.813 | 3 / 2 | 3.6 | Yes |
| 557313 |  MLS000849868 | C15H17N3OS | 287.381 | 3 / 3 | 2.5 | Yes |
| 308 |  MLS-0240968.0001 | C21H30N8O2 | 426.525 | 7 / 3 | 2.0 | Yes |
| 383 |  MLS000526436 | C18H31N3S | 321.527 | 2 / 2 | 3.7 | Yes |
| 533913 |  SCHEMBL739957 | C48H50N6O7 | 822.963 | 9 / 6 | 5.2 | No |
| 569 |  MLS001250385 | C18H22N2O5 | 346.383 | 5 / 0 | 3.7 | Yes |
| 441690 |  CHEMBL3426702 | C40H43N5O6 | 689.813 | 8 / 5 | 4.1 | No |
| 973 |  CHEMBL3298692 | C32H38N4O6 | 574.678 | 8 / 6 | 3.9 | No |
| 1013 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 1070 |  CHEMBL516056 | C28H44N2O8S | 568.726 | 10 / 6 | N/A | No |
| 1184 |  CHEMBL1243256 | C28H35N3O6S | 541.663 | 8 / 5 | 2.3 | No |
| 1244 |  CHEMBL556022 | C20H30Cl2N4O3S | 477.445 | 7 / 5 | N/A | N/A |
| 1341 |  CHEMBL2261203 | C29H36N4O5S2 | 584.75 | 8 / 4 | 3.9 | No |
| 1400 |  2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide | C15H14N4O4S | 346.361 | 8 / 1 | 2.3 | Yes |
| 1407 |  CHEMBL3265169 | C28H39FN4O4S | 546.702 | 8 / 3 | 3.3 | No |
| 1440 |  AC1OWPG0 | C18H15N3O6S | 401.393 | 9 / 1 | 2.4 | Yes |
| 1549 |  MLS000591296 | C22H20ClN3O3S | 441.93 | 6 / 1 | 4.1 | Yes |
| 1675 |  N-[(diallylamino)carbonothioyl]-4-methoxybenzamide | C15H18N2O2S | 290.381 | 3 / 1 | 2.8 | Yes |
| 1886 |  SMR000471067 | C31H29N3O4 | 507.59 | 4 / 0 | 4.1 | No |
| 459248 |  BDBM50097799 | C29H32N4O6S2 | 596.717 | 10 / 6 | 3.3 | No |
| 2182 |  CHEMBL458002 | C29H28ClN5O2 | 514.026 | 5 / 2 | 4.3 | No |
| 2286 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 2344 |  24090-38-8 | C11H10O3S | 222.258 | 4 / 1 | 2.2 | Yes |
| 2924 |  CHEMBL418308 | C35H32N4O3S2 | 620.786 | 8 / 3 | 6.0 | No |
| 3079 |  MLS001006036 | C19H16N2O3S | 352.408 | 4 / 1 | 3.1 | Yes |
| 3102 |  Prenalterol | C12H19NO3 | 225.288 | 4 / 3 | 1.4 | Yes |
| 3222 |  AC1M63SY | C13H10ClNO2S | 279.738 | 3 / 0 | 2.7 | Yes |
| 3278 |  CHEMBL475389 | C25H38N2O6S | 494.647 | 8 / 5 | 2.5 | Yes |
| 3507 |  CHEMBL2348219 | C25H35N3O6 | 473.57 | 7 / 5 | 2.3 | Yes |
| 3738 |  procaterol hydrochloride | C16H23ClN2O3 | 326.821 | 4 / 5 | N/A | N/A |
| 3949 |  AC1LGXBP | C20H23NO2 | 309.409 | 2 / 2 | 4.4 | Yes |
| 533923 |  SCHEMBL738884 | C46H54N6O7 | 802.973 | 9 / 6 | 4.3 | No |
| 4475 |  CHEMBL1773264 | C42H57N3O6S | 731.993 | 9 / 5 | 7.2 | No |
| 521580 |  CHEMBL3797876 | C17H21NO5 | 319.357 | 6 / 4 | 1.6 | Yes |
| 521585 |  CHEMBL3799593 | C17H21NO5 | 319.357 | 6 / 4 | 1.6 | Yes |
| 4600 |  CHEMBL208352 | C24H25ClN2O3 | 424.925 | 5 / 3 | 4.4 | Yes |
| 4779 |  MLS000697273 | C20H16N2O2S | 348.42 | 4 / 1 | 4.0 | Yes |
| 4851 |  MLS000776250 | C14H16N4O3S2 | 352.427 | 6 / 2 | 1.7 | Yes |
| 5146 |  CHEMBL466923 | C30H30N4O3 | 494.595 | 5 / 4 | 4.5 | Yes |
| 5272 |  CHEMBL279931 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5280 |  CHEMBL25133 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5282 |  CHEMBL26393 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5344 |  CHEMBL1359359 | C18H19NO6S | 377.411 | 8 / 5 | N/A | N/A |
| 5526 |  CHEMBL3128185 | C30H29FN4O2S | 528.646 | 7 / 3 | 4.2 | No |
| 5618 |  MLS000076295 | C21H23ClN4O3S | 446.95 | 7 / 0 | 4.0 | Yes |
| 6358 |  3-(4-methylphenyl)-6-phenyl-3,4-dihydro-1,3,5-triazine-2(1H)-thione | C16H15N3S | 281.377 | 2 / 1 | 3.3 | Yes |
| 6463 |  CHEMBL443435 | C29H41N3O10S | 623.718 | 12 / 7 | N/A | No |
| 6572 |  4-phenyl-3-buten-2-one thiosemicarbazone | C11H13N3S | 219.306 | 2 / 2 | 1.8 | Yes |
| 6669 |  CHEMBL1203989 | C24H27ClN4O4S | 503.014 | 6 / 5 | N/A | No |
| 6877 |  MLS000587278 | C23H25N3O3 | 391.471 | 5 / 2 | 4.3 | Yes |
| 6917 |  MLS000531823 | C21H22N2O4S2 | 430.537 | 6 / 1 | 3.0 | Yes |
| 463724 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 536146 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 7150 |  MLS000757136 | C17H10ClF3N2O2 | 366.724 | 6 / 1 | 4.8 | Yes |
| 7168 |  SMR000160170 | C13H22BrN5OS | 376.317 | 3 / 3 | 2.1 | Yes |
| 7285 |  CHEMBL1807874 | C23H31N3O4S | 445.578 | 7 / 4 | 2.2 | Yes |
| 7476 |  AC1PGOWB | C20H19NO5S | 385.434 | 6 / 1 | 2.8 | Yes |
| 7506 |  CHEMBL402501 | C30H40N2O4 | 492.66 | 5 / 5 | 4.2 | Yes |
| 7840 |  CHEMBL1078695 | C30H31N3O2 | 465.597 | 4 / 3 | 4.6 | Yes |
| 533942 |  US8551978, I-14 | C45H52N6O7 | 788.946 | 9 / 6 | 3.9 | No |
| 8237 |  MLS000420322 | C24H28ClN5O5 | 501.968 | 6 / 3 | 2.4 | No |
| 8578 |  CHEMBL585751 | C27H38N4O8S | 578.681 | 10 / 7 | -2.2 | No |
| 8601 |  CHEMBL34406 | C31H31N5O6S | 601.678 | 11 / 3 | 3.4 | No |
| 8891 |  MLS000075525 | C20H21N3O5S | 415.464 | 8 / 0 | 2.4 | Yes |
| 9404 |  CHEMBL100351 | C30H34N4O8S2 | 642.742 | 11 / 5 | -0.2 | No |
| 9407 |  3-benzoyl-6-methoxy-1-(4-methylbenzyl)quinolin-4(1H)-one | C25H21NO3 | 383.447 | 4 / 0 | 5.1 | No |
| 9624 |  CHEMBL1083053 | C30H35N3O4 | 501.627 | 6 / 1 | 4.2 | No |
| 9761 |  MLS000536654 | C18H26N6O | 342.447 | 5 / 2 | 2.6 | Yes |
| 9801 |  MLS000771237 | C19H19N3O3S | 369.439 | 6 / 1 | 3.0 | Yes |
| 9876 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 9943 |  SMR000120908 | C14H8ClNO3 | 273.672 | 4 / 0 | 3.6 | Yes |
| 10064 |  Bambuterol | C18H29N3O5 | 367.446 | 6 / 2 | 1.2 | Yes |
| 10106 |  CHEMBL604333 | C21H23F3N2O4 | 424.42 | 8 / 4 | 2.7 | Yes |
| 10202 |  SMR000627669 | C28H43N5O3 | 497.684 | 5 / 1 | 4.3 | Yes |
| 10300 |  CHEMBL230490 | C27H30Cl2N2O4 | 517.447 | 5 / 5 | 4.3 | No |
| 10443 |  SB 204070 hydrochloride | C19H27ClN2O4 | 382.885 | 6 / 1 | 3.5 | Yes |
| 10542 |  MLS002554631 | C32H40N4O5 | 560.695 | 5 / 2 | 2.6 | No |
| 10592 |  CHEMBL39269 | C30H28N4O4S | 540.638 | 8 / 3 | 3.8 | No |
| 10718 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10893 |  CHEMBL1085837 | C30H41NO7 | 527.658 | 8 / 5 | N/A | No |
| 557604 |  CHEMBL172042 | C18H20N2O5 | 344.367 | 6 / 3 | 1.9 | Yes |
| 10972 |  2-{[(3,4-dimethoxyphenyl)sulfonyl]anilino}-N-propylacetamide | C19H24N2O5S | 392.47 | 6 / 1 | 2.8 | Yes |
| 11082 |  60547-97-9 | C14H19N5O2 | 289.339 | 7 / 2 | 1.0 | Yes |
| 11087 |  SMR000647258 | C28H27N5O5 | 513.554 | 7 / 2 | 2.4 | No |
| 11533 |  3-MPPI | C23H25N5O3 | 419.485 | 5 / 2 | 2.7 | Yes |
| 533961 |  SCHEMBL741284 | C51H56N6O7 | 865.044 | 9 / 6 | 6.0 | No |
| 11697 |  Propranolol, L- | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11709 |  DEXPROPRANOLOL | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11716 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11761 |  MLS000877370 | C25H25ClN2O4 | 452.935 | 5 / 0 | 4.4 | Yes |
| 459322 |  CHEMBL550445 | C25H29N3O3S | 451.585 | 5 / 4 | 3.9 | Yes |
| 11819 |  CHEMBL466713 | C23H26N4O3 | 406.486 | 6 / 3 | 1.5 | Yes |
| 11890 |  CHEMBL551350 | C26H30N2O5 | 450.535 | 6 / 4 | 3.2 | Yes |
| 11953 |  SMR000063640 | C19H26ClF3N2O5S | 486.931 | 10 / 1 | 2.0 | Yes |
| 533965 |  SCHEMBL738913 | C50H54N6O7 | 851.017 | 9 / 6 | 5.5 | No |
| 536312 |  US8551978, I-25 | C47H48N6O7 | 808.936 | 9 / 6 | 4.8 | No |
| 12427 |  SMR000033354 | C20H23BrN2O5S | 483.377 | 7 / 0 | 2.9 | Yes |
| 12501 |  MLS001223940 | C18H21FN2S | 316.438 | 2 / 2 | 4.2 | Yes |
| 12977 |  CHEMBL1204006 | C25H30ClN3O2S | 472.044 | 4 / 5 | N/A | N/A |
| 13000 |  CHEMBL67998 | C33H38N4O5S | 602.75 | 7 / 6 | 5.7 | No |
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