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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	DADLE
Molecular formula	C29H39N5O7
IUPAC name	(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Molecular weight	569.659
Hydrogen bond acceptor	8
Hydrogen bond donor	7
XlogP	-1.9
Synonyms	C-54714 DADLE-OH SCHEMBL11124725 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid 63631-40-3 CS-0025794 H-Tyr-D-Ala-Gly-Phe-D-Leu ZINC14952092 (2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid BDBM21025 DADL HY-105343 (D-Ala2,D-Leu5)-Enkephalin 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid FT-0774214 Tyr-D-Ala-Gly-Phe-D-Leu AC1OCEJN D06YMS H-TYR-D-ALA-GLY-PHE-D-LEU-OH [D-Ala2, D-Leu5]-enkephalin (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid BW-180C MolPort-023-276-930 CHEMBL340032 GTPL1607 UNII-HB4QD9GL6F AKOS024457800 D0R0OG HB4QD9GL6F [D-Ala2-D-Leu5]enkephalin (2R,5S,11R,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid [ Show all ]
Inchi Key	ZHUJMSMQIPIPTF-IBURTVSXSA-N
Inchi ID	InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1
PubChem CID	6917707
ChEMBL	CHEMBL340032
IUPHAR	1607
BindingDB	21025
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
428858	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
428863	Delta-type opioid receptor	P32300	Oprd1	Mus musculus (Mouse)	372
428864	Delta-type opioid receptor	P33533	Oprd1	Rattus norvegicus (Rat)	372
462856	Delta-type opioid receptor	P79291	OPRD1	Sus scrofa (Pig)	228
428861	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
428862	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
428866	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
428856	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
428857	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
428859	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
428860	Mu-type opioid receptor	P79350	OPRM1	Bos taurus (Bovine)	401
428865	Mu-type opioid receptor	P42866	Oprm1	Mus musculus (Mouse)	398

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