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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	apraclonidine
Molecular formula	C9H10Cl2N4
IUPAC name	2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
Molecular weight	245.107
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	1.3
Synonyms	C9H10Cl2N4 Iopidine Eye NCGC00015033-01 para-aminoclonidine 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine AKOS025401361 Apraclonidinum CHEBI:2788 FT-0602879 L000686 NCGC00162050-01 SCHEMBL34127 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 2-(4-amino-2,6-dichlorophenylimino) imidazolidine 843CEN85DI Aminoclonidine, p Apraclonidina BDBM81926 D07461 Iopidine Lopac0_000033 p-aminoclonidine 1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)- ZINC20231 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine AJ-09624 Apraclonidine (INN) CAS_66711-21-5 DB00964 K093 NCGC00015033-02 PDSP1_000790 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine 711A215 AL-02145 Apraclonidinum [INN-Latin] GTPL7117 L013394 NSC_51763 SMP1_000016 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine (p-aminoclonidine) 2-(4-amino-2,6-dichlorophenylimino)imidazolidine AC-12697 AN-38453 Apraclonidina [INN-Spanish] C07668 D0MT0M Iopidine (TN) LS-176536 P-AMINOCLONIDINE2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 1,4-Benzenediamine, 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)- 2,6-DICHLORO-N1-(IMIDAZOLIDIN-2-YLIDENE)BENZENE-1,4-DIAMINE 66711-21-5 AKOS016010355 Apraclonidine [INN:BAN] CCG-204129 DTXSID1048415 KB-226140 NCGC00015033-03 PDSP2_000778 2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2-(4-Amino-2,6-dichlorophenylamino)-2-imidazoline ALO 2145 BDBM50021812 CHEMBL647 IEJXVRYNEISIKR-UHFFFAOYSA-N Lopac-A-0779 p-amino clonidine UNII-843CEN85DI 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine(p-Aminoclonidine) 4-Aminoclonidine AC1L1D6L Aplonidine [ Show all ]
Inchi Key	IEJXVRYNEISIKR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)
PubChem CID	2216
ChEMBL	CHEMBL647
IUPHAR	7117
BindingDB	50021812, 81926
DrugBank	DB00964
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
131210	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
131207	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
131214	Alpha-2A adrenergic receptor	P18871	ADRA2A	Sus scrofa (Pig)	450
131208	Alpha-2B adrenergic receptor	P19328	Adra2b	Rattus norvegicus (Rat)	453
131212	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
131209	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
555995	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
131211	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
131213	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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