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GPCR

Name	Alpha-1A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1A
Synonym	alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c adrenergic receptor, alpha 1a alpha 1A-adrenoceptor alpha 1A-adrenoreceptor alpha1c alpha 1C-adrenergic receptor alpha-1A adrenergic receptor Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor Alpha-adrenergic receptor 1c alpha1A-adrenoceptor [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma Hypertension Major depressive disorder Pain Post-traumatic stress disorder Prostate cancer; Benign prostatic hyperplasia Prostate disease Prostate hyperplasia Stress urinary incontinence Unspecified [ Show all ]
Length	466
Amino acid sequence	MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
UniProt	P35348
Protein Data Bank	N/A
GPCR-HGmod model	P35348
3D structure model	This predicted structure model is from GPCR-EXP P35348.
BioLiP	N/A
Therapeutic Target Database	T92609
ChEMBL	CHEMBL229
IUPHAR	22
DrugBank	BE0000501

Ligand

Name	apraclonidine
Molecular formula	C9H10Cl2N4
IUPAC name	2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
Molecular weight	245.107
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	1.3
Synonyms	2-(4-amino-2,6-dichlorophenylimino) imidazolidine 843CEN85DI Aminoclonidine, p Apraclonidinum CHEBI:2788 FT-0602879 L000686 NCGC00162050-01 SCHEMBL34127 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine AJ-09624 Apraclonidina BDBM81926 D07461 Iopidine Lopac0_000033 p-aminoclonidine 1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)- ZINC20231 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine 711A215 AL-02145 Apraclonidine (INN) CAS_66711-21-5 DB00964 K093 NCGC00015033-02 PDSP1_000790 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine (p-aminoclonidine) 2-(4-amino-2,6-dichlorophenylimino)imidazolidine AC-12697 AN-38453 Apraclonidinum [INN-Latin] GTPL7117 L013394 NSC_51763 SMP1_000016 2,6-DICHLORO-N1-(IMIDAZOLIDIN-2-YLIDENE)BENZENE-1,4-DIAMINE 66711-21-5 AKOS016010355 Apraclonidina [INN-Spanish] C07668 D0MT0M Iopidine (TN) LS-176536 P-AMINOCLONIDINE2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 1,4-Benzenediamine, 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)- 2-(4-Amino-2,6-dichlorophenylamino)-2-imidazoline ALO 2145 Apraclonidine [INN:BAN] CCG-204129 DTXSID1048415 KB-226140 NCGC00015033-03 PDSP2_000778 2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine(p-Aminoclonidine) 4-Aminoclonidine AC1L1D6L Aplonidine BDBM50021812 CHEMBL647 IEJXVRYNEISIKR-UHFFFAOYSA-N Lopac-A-0779 p-amino clonidine UNII-843CEN85DI 2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine AKOS025401361 C9H10Cl2N4 Iopidine Eye NCGC00015033-01 para-aminoclonidine 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine [ Show all ]
Inchi Key	IEJXVRYNEISIKR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)
PubChem CID	2216
ChEMBL	CHEMBL647
IUPHAR	7117
BindingDB	50021812, 81926
DrugBank	DB00964
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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