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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	apraclonidine
Molecular formula	C9H10Cl2N4
IUPAC name	2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
Molecular weight	245.107
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	1.3
Synonyms	2-(4-amino-2,6-dichlorophenylimino) imidazolidine 843CEN85DI Aminoclonidine, p Apraclonidinum CHEBI:2788 FT-0602879 L000686 NCGC00162050-01 SCHEMBL34127 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine AJ-09624 Apraclonidina BDBM81926 D07461 Iopidine Lopac0_000033 p-aminoclonidine 1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)- ZINC20231 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine 711A215 AL-02145 Apraclonidine (INN) CAS_66711-21-5 DB00964 K093 NCGC00015033-02 PDSP1_000790 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine (p-aminoclonidine) 2-(4-amino-2,6-dichlorophenylimino)imidazolidine AC-12697 AN-38453 Apraclonidinum [INN-Latin] GTPL7117 L013394 NSC_51763 SMP1_000016 2,6-DICHLORO-N1-(IMIDAZOLIDIN-2-YLIDENE)BENZENE-1,4-DIAMINE 66711-21-5 AKOS016010355 Apraclonidina [INN-Spanish] C07668 D0MT0M Iopidine (TN) LS-176536 P-AMINOCLONIDINE2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 1,4-Benzenediamine, 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)- 2-(4-Amino-2,6-dichlorophenylamino)-2-imidazoline ALO 2145 Apraclonidine [INN:BAN] CCG-204129 DTXSID1048415 KB-226140 NCGC00015033-03 PDSP2_000778 2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine(p-Aminoclonidine) 4-Aminoclonidine AC1L1D6L Aplonidine BDBM50021812 CHEMBL647 IEJXVRYNEISIKR-UHFFFAOYSA-N Lopac-A-0779 p-amino clonidine UNII-843CEN85DI 2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine AKOS025401361 C9H10Cl2N4 Iopidine Eye NCGC00015033-01 para-aminoclonidine 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine [ Show all ]
Inchi Key	IEJXVRYNEISIKR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)
PubChem CID	2216
ChEMBL	CHEMBL647
IUPHAR	7117
BindingDB	50021812, 81926
DrugBank	DB00964
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID2138666	BindingDB

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