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GPCR

Name	Alpha-2A adrenergic receptor
Species	Sus scrofa (Pig)
Gene	ADRA2A
Synonym	Alpha-2A adrenoceptor Alpha-2A adrenoreceptor Alpha-2AAR
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPEAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKAGGGGQQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAAALPGGAERRPNGLGPERGVGRVGAEAEPLPVQLNGAPGEPAPAGPRDADGLDLEESSSSEHAERPPGPRRSERGPRAKSKARASQVKPGDSLPRRGPGAPGPGAPATGAGEERGGVAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P18871
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2350
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	apraclonidine
Molecular formula	C9H10Cl2N4
IUPAC name	2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
Molecular weight	245.107
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	1.3
Synonyms	C9H10Cl2N4 Iopidine Eye NCGC00015033-01 para-aminoclonidine 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine AKOS025401361 Apraclonidinum CHEBI:2788 FT-0602879 L000686 NCGC00162050-01 SCHEMBL34127 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 2-(4-amino-2,6-dichlorophenylimino) imidazolidine 843CEN85DI Aminoclonidine, p Apraclonidina BDBM81926 D07461 Iopidine Lopac0_000033 p-aminoclonidine 1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)- ZINC20231 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine AJ-09624 Apraclonidine (INN) CAS_66711-21-5 DB00964 K093 NCGC00015033-02 PDSP1_000790 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine 711A215 AL-02145 Apraclonidinum [INN-Latin] GTPL7117 L013394 NSC_51763 SMP1_000016 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine (p-aminoclonidine) 2-(4-amino-2,6-dichlorophenylimino)imidazolidine AC-12697 AN-38453 Apraclonidina [INN-Spanish] C07668 D0MT0M Iopidine (TN) LS-176536 P-AMINOCLONIDINE2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine 1,4-Benzenediamine, 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)- 2,6-DICHLORO-N1-(IMIDAZOLIDIN-2-YLIDENE)BENZENE-1,4-DIAMINE 66711-21-5 AKOS016010355 Apraclonidine [INN:BAN] CCG-204129 DTXSID1048415 KB-226140 NCGC00015033-03 PDSP2_000778 2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine 2-(4-Amino-2,6-dichlorophenylamino)-2-imidazoline ALO 2145 BDBM50021812 CHEMBL647 IEJXVRYNEISIKR-UHFFFAOYSA-N Lopac-A-0779 p-amino clonidine UNII-843CEN85DI 2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-diamine(p-Aminoclonidine) 4-Aminoclonidine AC1L1D6L Aplonidine [ Show all ]
Inchi Key	IEJXVRYNEISIKR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)
PubChem CID	2216
ChEMBL	CHEMBL647
IUPHAR	7117
BindingDB	50021812, 81926
DrugBank	DB00964
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	288.4 nM	PMID10900230	BindingDB

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