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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	L-732,138
Molecular formula	C22H18F6N2O3
IUPAC name	[3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-indol-3-yl)propanoate
Molecular weight	472.387
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	4.7
Synonyms	MLS002172463 NCGC00015066-01 SR-01000075194 [3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-indol-3-yl)propanoate API0007694 DTXSID20163989 L-732138 N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester NCGC00024832-03 SR-01000597431-1 BIDD:GT0377 HMS2234A11 Lopac-A-5330 N-Acetyl-L-trytophan 3,5-bis(trifluoromethyl)benzyl ester SCHEMBL3682000 ZB014526 (S)-3,5-bis(trifluoromethyl)benzyl 2-acetamido-3-(1H-indol-3-yl)propanoate AC1L31NR CHEMBL22870 L 732138 LS-158105 N-Acetyl-L-trp-3,5-bistrifluoromethylbenzyl ester NCGC00024832-01 SR-01000075194-1 3,5-Bis(tfm)Bz nactrp B6478 EU-0100028 L-Tryptophan, N-acetyl-, (3,5-bis(trifluoromethyl)phenyl)methyl ester N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester, >=99% (TLC), powder NCGC00024832-04 Tocris-0868 A 5330 CCG-204124 HMS3260E17 Lopac0_000028 MFCD00237267 N-Acetyltryptophan 3,5-bis(trifluoromethyl)benzyl ester SMR001254094 ZINC598586 148451-96-1 AKOS015898307 D08ZBV N-acetyl-l-tryptophan 3,5-bis(trifluoromethyl) benzyl ester NCGC00024832-02 SR-01000597431 3,5-Bis(trifluoromethyl)benzyl N-acetyltryptophan BDBM21016 GTPL9461 L732138 N-Acetyl-L-tryptophan-3,5-bistrifluoromethylbenzyl ester NCGC00260713-01 Tox21_500028 AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER I10-1459 LP00028 [ Show all ]
Inchi Key	BYYQYXVAWXAYQC-IBGZPJMESA-N
Inchi ID	InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
PubChem CID	132837
ChEMBL	CHEMBL22870
IUPHAR	9461
BindingDB	21016
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
36218	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
36214	Neuromedin-K receptor	P16177	Tacr3	Rattus norvegicus (Rat)	452
36219	Neuromedin-K receptor	P29371	TACR3	Homo sapiens (Human)	465
36220	Neuropeptide S receptor	Q6W5P4	NPSR1	Homo sapiens (Human)	371
467379	Parathyroid hormone/parathyroid hormone-related peptide receptor	Q03431	PTH1R	Homo sapiens (Human)	593
36213	Substance-K receptor	P79218	TACR2	Oryctolagus cuniculus (Rabbit)	384
36215	Substance-K receptor	P21452	TACR2	Homo sapiens (Human)	398
36217	Substance-K receptor	P16610	Tacr2	Rattus norvegicus (Rat)	390
36211	Substance-P receptor	P25103	TACR1	Homo sapiens (Human)	407
36212	Substance-P receptor	P30547	TACR1	Cavia porcellus (Guinea pig)	407
36216	Substance-P receptor	P14600	Tacr1	Rattus norvegicus (Rat)	407

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