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| Name | Substance-P receptor |
|---|---|
| Species | Cavia porcellus (Guinea pig) |
| Gene | TACR1 |
| Synonym | NK-1 receptor NK-1R SPR Tachykinin receptor 1 |
| Disease | N/A for non-human GPCRs |
| Length | 407 |
| Amino acid sequence | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS |
| UniProt | P30547 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL3942 |
| IUPHAR | N/A |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 1516 |  CHEMBL556537 | C70H89F6N11O15 | 1438.53 | 22 / 14 | 5.8 | No |
| 1835 |  CHEMBL2304114 | C97H126N18O19S | 1880.24 | 21 / 15 | 7.8 | No |
| 2379 |  CHEMBL418124 | C38H42ClN5O8 | 732.231 | 8 / 4 | 4.9 | No |
| 2492 |  Substance P | C63H98N18O13S | 1347.65 | 17 / 15 | -2.3 | No |
| 2799 |  sub-stance p | C63H98N18O13S | 1347.65 | 17 / 15 | -2.3 | No |
| 463229 |  CHEMBL3609619 | C32H30F6N4O5 | 664.605 | 12 / 5 | 4.5 | No |
| 3011 |  CHEMBL303116 | C30H32N4O3 | 496.611 | 3 / 3 | 4.3 | Yes |
| 3084 |  CHEMBL291602 | C29H35N7O7 | 593.641 | 7 / 7 | -0.8 | No |
| 3171 |  CHEMBL557188 | C60H72F6N10O9 | 1191.29 | 16 / 10 | 7.4 | No |
| 3265 |  CHEMBL322194 | C39H48N4O6 | 668.835 | 8 / 0 | 5.4 | No |
| 3952 |  CHEMBL441206 | C75H109N19O13 | 1484.82 | 16 / 15 | 0.5 | No |
| 4012 |  CHEMBL361596 | C33H34F6N4O2 | 632.651 | 11 / 0 | 7.2 | No |
| 4782 |  CHEMBL302892 | C37H38N4O4 | 602.735 | 4 / 2 | 5.0 | No |
| 5576 |  CHEMBL330172 | C41H45N5O5 | 687.841 | 8 / 0 | 5.8 | No |
| 5638 |  CHEMBL544284 | C33H35N5O6 | 597.672 | 7 / 4 | 2.6 | No |
| 8190 |  CHEMBL293726 | C35H38N4O7 | 626.71 | 7 / 3 | 5.0 | No |
| 9055 |  CHEMBL369859 | C34H39Cl2N3O6 | 656.601 | 7 / 1 | 4.8 | No |
| 9571 |  CHEMBL355506 | C28H29Cl2N5O3 | 554.472 | 6 / 1 | 3.2 | No |
| 9961 |  CHEMBL387670 | C61H73F6N9O10 | 1206.3 | 17 / 8 | 8.1 | No |
| 10380 |  CHEMBL96442 | C41H45N5O5 | 687.841 | 8 / 0 | 5.8 | No |
| 11675 |  CHEMBL384541 | C63H96N14O12S | 1273.61 | 15 / 12 | 1.2 | No |
| 12554 |  CHEMBL389724 | C27H26F6N4O2 | 552.521 | 11 / 0 | 6.3 | No |
| 12555 |  CHEMBL229187 | C27H26F6N4O2 | 552.521 | 11 / 0 | 6.3 | No |
| 13753 |  CHEMBL352734 | C29H30Cl2N4O3 | 553.484 | 5 / 1 | 4.2 | No |
| 13756 |  CHEMBL291868 | C31H31N3O4S | 541.666 | 5 / 2 | 4.6 | No |
| 13987 |  CHEMBL2304107 | C83H118N18O17S | 1672.03 | 19 / 15 | 3.6 | No |
| 14028 |  CHEMBL1766208 | C61H74F6N10O9S | 1237.37 | 17 / 10 | 7.3 | No |
| 14083 |  CHEMBL611925 | C57H64F6N10O9S2 | 1211.31 | 18 / 10 | 6.0 | No |
| 14096 |  CHEMBL611924 | C57H64F6N10O9S2 | 1211.31 | 18 / 10 | 6.0 | No |
| 16020 |  CHEMBL152239 | C27H29FN2 | 400.541 | 3 / 1 | 5.5 | No |
| 16138 |  H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl | C52H62N8O9 | 943.115 | 10 / 8 | 5.0 | No |
| 16530 |  CHEMBL335248 | C32H53N7O6S | 663.879 | 8 / 7 | 1.4 | No |
| 17372 |  CHEMBL291634 | C28H28N4O3 | 468.557 | 3 / 3 | 3.7 | Yes |
| 18051 |  CHEMBL2304032 | C80H112N16O17S2 | 1633.99 | 20 / 13 | 4.3 | No |
| 18055 |  CHEMBL2079568 | C80H112N16O17S2 | 1633.99 | 20 / 14 | 4.7 | No |
| 18247 |  CHEMBL67508 | C32H39Cl4N5O4 | 699.495 | 6 / 1 | 5.6 | No |
| 18250 |  CHEMBL66635 | C32H39Cl4N5O4 | 699.495 | 6 / 1 | 5.6 | No |
| 18252 |  CHEMBL441252 | C32H39Cl4N5O4 | 699.495 | 6 / 1 | 5.6 | No |
| 18658 |  CHEMBL39595 | C39H50Cl2IN3O2 | 790.652 | 4 / 1 | N/A | No |
| 20864 |  CHEMBL449091 | C45H64N10O10 | 905.067 | 10 / 10 | 0.2 | No |
| 21971 |  L-Serine,N-[1-oxo-3-(2-pentylphenyl)propyl]-L-threonyl-(aE)-a,b-didehydro-N-methyltyrosyl-L-leucyl-D-phenylalanyl-L-allothreonyl-L-asparaginyl-,(7®1)-lactone | C54H72N8O13 | 1041.21 | 13 / 10 | 4.9 | No |
| 22031 |  CHEMBL94834 | C43H44F4N4O5 | 772.842 | 11 / 0 | 7.8 | No |
| 22462 |  CHEMBL303548 | C36H36N4O4 | 588.708 | 4 / 2 | 4.6 | No |
| 22468 |  L001421 | C36H36N4O4 | 588.708 | 4 / 2 | 4.6 | No |
| 22984 |  CHEMBL426363 | C56H63F6N9O10 | 1136.16 | 17 / 9 | 6.1 | No |
| 23620 |  UNII-G9BL4978MZ | C27H25Cl2F6N3O3 | 624.405 | 9 / 2 | 6.2 | No |
| 24363 |  CHEMBL354170 | C32H34Cl2N4O4 | 609.548 | 5 / 2 | 4.1 | No |
| 24422 |  CHEMBL292256 | C32H33N5O6 | 583.645 | 6 / 2 | 3.2 | No |
| 26678 |  CHEMBL411176 | C50H70N10O10S2 | 1035.29 | 13 / 9 | 3.6 | No |
| 26726 |  CHEMBL538131 | C64H80F6N10O15 | 1343.39 | 22 / 15 | 4.8 | No |
| 27404 |  CHEMBL2370937 | C64H99N20O13+ | 1356.62 | 17 / 15 | -0.9 | No |
| 29348 |  CHEMBL443237 | C30H31Cl2N3O3 | 552.496 | 4 / 1 | 5.0 | No |
| 29388 |  CHEMBL293200 | C43H45N5O6 | 727.862 | 6 / 5 | 7.3 | No |
| 29460 |  CHEMBL2304129 | C81H113N17O18S | 1644.96 | 20 / 13 | 3.2 | No |
| 29736 |  CHEMBL441454 | C45H66N12O7S | 919.16 | 10 / 10 | 1.1 | No |
| 558182 |  CHEMBL288123 | C38H46Cl2N3O3+ | 663.704 | 3 / 1 | 6.8 | No |
| 30738 |  CHEMBL265115 | C49H76N12O9S | 1009.28 | 11 / 10 | 0.9 | No |
| 31771 |  CHEMBL266884 | C41H52N8O7S | 800.976 | 8 / 6 | 2.8 | No |
| 442911 |  CHEMBL3349688 | C41H52N8O7S | 800.976 | 8 / 6 | 2.8 | No |
| 32037 |  CHEMBL320003 | C35H38Cl2N4O5 | 665.612 | 7 / 1 | 6.6 | No |
| 34850 |  CHEMBL262048 | C39H57N7O6S | 751.988 | 8 / 6 | 3.0 | No |
| 34851 |  CHEMBL407511 | C39H57N7O6S | 751.988 | 8 / 6 | 3.0 | No |
| 36212 |  L-732,138 | C22H18F6N2O3 | 472.387 | 9 / 2 | 4.7 | Yes |
| 36404 |  CHEMBL225297 | C39H47N9O7S | 785.921 | 10 / 7 | 1.2 | No |
| 37244 |  CHEMBL307433 | C45H66N10O10 | 907.083 | 10 / 10 | 0.8 | No |
| 37580 |  CHEMBL264821 | C34H38N4O4 | 566.702 | 4 / 2 | 4.1 | No |
| 38212 |  CHEMBL294737 | C32H39N5O8 | 621.691 | 8 / 4 | 2.7 | No |
| 38492 |  CHEMBL436879 | C69H108N18O13S | 1429.8 | 17 / 14 | -0.5 | No |
| 38537 |  CHEMBL543338 | C32H38ClN5O3 | 576.138 | 4 / 5 | N/A | No |
| 39076 |  CHEMBL2304085 | C64H97N15O12S | 1300.63 | 16 / 10 | 1.6 | No |
| 39814 |  CHEMBL387937 | C33H35F6N5O3 | 663.665 | 12 / 0 | 6.4 | No |
| 39815 |  CHEMBL229514 | C33H35F6N5O3 | 663.665 | 12 / 0 | 6.4 | No |
| 41473 |  CHEMBL95076 | C42H48N4O7 | 720.867 | 9 / 0 | 5.6 | No |
| 41507 |  CHEMBL2304128 | C53H78N10O13S | 1095.32 | 14 / 8 | 2.4 | No |
| 42667 |  CHEMBL171876 | C31H35Cl2N3O6S | 648.596 | 8 / 1 | 4.6 | No |
| 43104 |  CHEMBL157858 | C37H43N5O6 | 653.78 | 6 / 4 | 3.4 | No |
| 43822 |  CHEMBL2419542 | C49H53F6N7O8 | 981.994 | 15 / 8 | 6.9 | No |
| 44533 |  CHEMBL2304101 | C83H111N19O18S | 1694.98 | 20 / 17 | 2.9 | No |
| 44633 |  CHEMBL294288 | C35H45N5O8 | 663.772 | 8 / 4 | 4.0 | No |
| 522895 |  CHEMBL3735298 | C57H66F7N9O8 | 1138.2 | 16 / 8 | 7.2 | No |
| 47636 |  CHEMBL2304093 | C79H107N15O16S | 1554.87 | 18 / 11 | 5.6 | No |
| 47796 |  CHEMBL119990 | C29H31NO3S | 473.631 | 4 / 0 | 4.5 | Yes |
| 48600 |  CHEMBL2304098 | C76H106N20O14S | 1555.87 | 18 / 18 | -1.6 | No |
| 48838 |  CHEMBL308363 | C37H44N6O6 | 668.795 | 6 / 6 | 2.9 | No |
| 49103 |  CHEMBL353480 | C33H37Cl2N3O6 | 642.574 | 8 / 0 | 5.3 | No |
| 49736 |  CHEMBL2370054 | C49H67N9O11 | 958.127 | 11 / 8 | 3.6 | No |
| 49927 |  CHEMBL182146 | C28H25F6N3O3 | 565.516 | 11 / 0 | 5.7 | No |
| 50307 |  CHEMBL94726 | C43H45FN4O7 | 748.852 | 10 / 0 | 6.8 | No |
| 50377 |  CHEMBL435717 | C53H59N9O6 | 918.112 | 8 / 8 | 6.4 | No |
| 50428 |  Substance P, C-terminal pentapeptide | C36H49N7O7S | 723.89 | 8 / 7 | 2.1 | No |
| 50838 |  CHEMBL318369 | C41H48Cl2N4O7 | 779.756 | 9 / 0 | 7.0 | No |
| 52028 |  GR 94800 | C49H61N9O8 | 904.082 | 8 / 7 | 4.4 | No |
| 52433 |  CHEMBL406889 | C56H78N12O11S | 1127.37 | 13 / 11 | 3.9 | No |
| 52487 |  76260-78-1 | C64H99N17O14S | 1362.66 | 18 / 14 | -1.3 | No |
| 52489 |  CHEMBL2304030 | C64H99N17O14S | 1362.66 | 18 / 14 | -1.3 | No |
| 52491 |  CHEMBL2304102 | C64H99N17O14S | 1362.66 | 18 / 14 | -1.3 | No |
| 52731 |  CHEMBL66106 | C30H36Cl4N4O3 | 642.443 | 5 / 0 | 6.7 | No |
| 52736 |  CHEMBL68060 | C30H36Cl4N4O3 | 642.443 | 5 / 0 | 6.7 | No |
| 53165 |  CHEMBL354288 | C34H39Cl2N3O6 | 656.601 | 7 / 1 | 5.2 | No |
| 53330 |  CHEMBL289727 | C38H48Cl2IN3O2 | 776.625 | 4 / 1 | N/A | No |
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