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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Substance P, C-terminal pentapeptide
Molecular formula	C36H49N7O7S
IUPAC name	(2S)-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	723.89
Hydrogen bond acceptor	8
Hydrogen bond donor	7
XlogP	2.1
Synonyms	AC1Q5JOZ FT-0771879 Substance P (6-11), hexapeptide-pglu(6)- (S)-N-((5S,8S,14S,17S)-14-benzyl-5-carbamoyl-8-isobutyl-7,10,13,16-tetraoxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadecan-17-yl)-5-oxopyrrolidine-2-carboxamide C-54178 L-Methioninamide,5-oxo-L-prolyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- (9CI) 61123-13-5 CTK5B2726 pGlu6-Phe-Phe-Gly-Leu-Met-NH2 (2S)-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-oxopyrrolidine-2-carboxamide AKOS030574013 Glp-Phe-Phe-Gly-Leu-Met-NH2 Substance P (6-11), pglu(6)- 5-oxo-l-prolyl-l-phenylalanyl-l-phenylalanylglycyl-l-leucyl-l-methioninamide 6-Pglu-SP(6-11) LS-147259 ZINC26492545 AC1L4MMV E-SP(7-11) PYR-PHE-PHE-GLY-LEU-MET-NH2 (pGlu6)substance P(6-11) BDBM50007963 L-Methioninamide, 5-oxo-L-prolyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- Substance P (6-11), pyroglutamic acid- 5-Oxo-pro-phe-phe-gly-leu-met-amide 6-Pglu-substance P (6-11) CHEMBL441061 pGlu-Phe-Phe-Gly-Leu-Met-NH2 [ Show all ]
Inchi Key	CTTLAZLIKHEYJW-ZIUUJSQJSA-N
Inchi ID	InChI=1S/C36H49N7O7S/c1-22(2)18-27(35(49)41-25(32(37)46)16-17-51-3)40-31(45)21-38-33(47)28(19-23-10-6-4-7-11-23)42-36(50)29(20-24-12-8-5-9-13-24)43-34(48)26-14-15-30(44)39-26/h4-13,22,25-29H,14-21H2,1-3H3,(H2,37,46)(H,38,47)(H,39,44)(H,40,45)(H,41,49)(H,42,50)(H,43,48)/t25-,26-,27-,28-,29-/m0/s1
PubChem CID	188348
ChEMBL	CHEMBL441061
IUPHAR	N/A
BindingDB	50007963
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
50427	Neuromedin-K receptor	P30098	TACR3	Cavia porcellus (Guinea pig)	440
50428	Substance-P receptor	P30547	TACR1	Cavia porcellus (Guinea pig)	407

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