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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Substance-P receptor
Species	Cavia porcellus (Guinea pig)
Gene	TACR1
Synonym	NK-1 receptor NK-1R SPR Tachykinin receptor 1
Disease	N/A for non-human GPCRs
Length	407
Amino acid sequence	MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
UniProt	P30547
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3942
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL353480
Molecular formula	C33H37Cl2N3O6
IUPAC name	1-[4-[4-[2-[(5R)-5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)-1,3-oxazolidin-5-yl]ethyl]piperazin-1-yl]phenyl]ethanone
Molecular weight	642.574
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	5.3
Synonyms	1-[2-[(5R)-3-(3,4,5-Trimethoxybenzoyl)-5-(3,4-dichlorophenyl)-5alpha-oxazolidinyl]ethyl]-4-(4-acetylphenyl)piperazine BDBM50217518
Inchi Key	CRTJVWSMULCYJN-XIFFEERXSA-N
Inchi ID	InChI=1S/C33H37Cl2N3O6/c1-22(39)23-5-8-26(9-6-23)37-15-13-36(14-16-37)12-11-33(25-7-10-27(34)28(35)19-25)20-38(21-44-33)32(40)24-17-29(41-2)31(43-4)30(18-24)42-3/h5-10,17-19H,11-16,20-21H2,1-4H3/t33-/m0/s1
PubChem CID	44382141
ChEMBL	CHEMBL353480
IUPHAR	N/A
BindingDB	50217518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.018 ug.mL-1	PMID10206553	ChEMBL
IC50	18.0 nM	PMID10206553	BindingDB

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