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Name | Substance-P receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | TACR1 |
Synonym | NK-1 receptor NK-1R SPR Tachykinin receptor 1 |
Disease | N/A for non-human GPCRs |
Length | 407 |
Amino acid sequence | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS |
UniProt | P30547 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3942 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL303116 |
---|---|
Molecular formula | C30H32N4O3 |
IUPAC name | N-[1-[[(2R)-1-[benzyl(methyl)amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]-1H-indole-3-carboxamide |
Molecular weight | 496.611 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 3 |
XlogP | 4.3 |
Synonyms | BDBM50030207 1H-Indole-3-carboxylic acid {1-[(R)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-1-methyl-ethyl}-amide |
Inchi Key | ADROAEPHWXPRTM-AREMUKBSSA-N |
Inchi ID | InChI=1S/C30H32N4O3/c1-30(2,33-27(35)24-19-31-25-17-11-10-16-23(24)25)29(37)32-26(18-21-12-6-4-7-13-21)28(36)34(3)20-22-14-8-5-9-15-22/h4-17,19,26,31H,18,20H2,1-3H3,(H,32,37)(H,33,35)/t26-/m1/s1 |
PubChem CID | 44306226 |
ChEMBL | CHEMBL303116 |
IUPHAR | N/A |
BindingDB | 50030207 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 23.0 nM | PMID7518002 | BindingDB,ChEMBL |
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