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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Substance-P receptor
Species	Cavia porcellus (Guinea pig)
Gene	TACR1
Synonym	NK-1 receptor NK-1R SPR Tachykinin receptor 1
Disease	N/A for non-human GPCRs
Length	407
Amino acid sequence	MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
UniProt	P30547
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3942
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL354288
Molecular formula	C34H39Cl2N3O6
IUPAC name	1-[3-[(5R)-5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)-1,3-oxazolidin-5-yl]propyl]-4-phenylpiperidine-4-carboxamide
Molecular weight	656.601
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.2
Synonyms	BDBM50217516 SCHEMBL7495626 1-[3-[(5R)-3-(3,4,5-Trimethoxybenzoyl)-5-(3,4-dichlorophenyl)-5alpha-oxazolidinyl]propyl]-4-phenylpiperidine-4-carboxamide
Inchi Key	CXUPEUUCLWUJBN-UMSFTDKQSA-N
Inchi ID	InChI=1S/C34H39Cl2N3O6/c1-42-28-18-23(19-29(43-2)30(28)44-3)31(40)39-21-34(45-22-39,25-10-11-26(35)27(36)20-25)12-7-15-38-16-13-33(14-17-38,32(37)41)24-8-5-4-6-9-24/h4-6,8-11,18-20H,7,12-17,21-22H2,1-3H3,(H2,37,41)/t34-/m0/s1
PubChem CID	44382306
ChEMBL	CHEMBL354288
IUPHAR	N/A
BindingDB	50217516
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.023 ug.mL-1	PMID10206553	ChEMBL
IC50	23.0 nM	PMID10206553	BindingDB

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