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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Substance-P receptor
Species	Cavia porcellus (Guinea pig)
Gene	TACR1
Synonym	NK-1 receptor NK-1R SPR Tachykinin receptor 1
Disease	N/A for non-human GPCRs
Length	407
Amino acid sequence	MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
UniProt	P30547
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3942
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL264821
Molecular formula	C34H38N4O4
IUPAC name	(4R)-N-[(2R)-1-[benzyl(methyl)amino]-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-1-(1-propan-2-ylindole-3-carbonyl)pyrrolidine-2-carboxamide
Molecular weight	566.702
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.1
Synonyms	(R)-4-Hydroxy-1-(1-isopropyl-1H-indole-3-carbonyl)-pyrrolidine-2-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethyl]-amide BDBM50030209
Inchi Key	CAWAMDJVBURMIX-OYASOLBTSA-N
Inchi ID	InChI=1S/C34H38N4O4/c1-23(2)37-22-28(27-16-10-11-17-30(27)37)33(41)38-21-26(39)19-31(38)32(40)35-29(18-24-12-6-4-7-13-24)34(42)36(3)20-25-14-8-5-9-15-25/h4-17,22-23,26,29,31,39H,18-21H2,1-3H3,(H,35,40)/t26-,29-,31?/m1/s1
PubChem CID	44306435
ChEMBL	CHEMBL264821
IUPHAR	N/A
BindingDB	50030209
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	15.9 nM	PMID7518002	ChEMBL
IC50	16.0 nM	PMID7518002	BindingDB

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