Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
521549	SCHEMBL2193122	C14H19N3O	245.326	2 / 1	2.1	Yes
6299	3-CYANO-5-HYDROXYBENZOIC ACID	C8H5NO3	163.132	4 / 2	0.9	Yes
521659	SCHEMBL2194444	C11H7ClN4O	246.654	3 / 1	1.0	Yes
521702	SCHEMBL2196084	C12H7BrClN3O	324.562	2 / 1	3.1	Yes
8607	CHEMBL482698	C20H21NO4	339.391	4 / 3	3.8	Yes
521873	SCHEMBL2194867	C12H8ClN3O	245.666	2 / 1	2.1	Yes
14305	5-Hydroxynicotinic acid	C6H5NO3	139.11	4 / 2	0.0	Yes
521962	SCHEMBL2191670	C12H7ClFN3O	263.656	3 / 1	2.2	Yes
521966	SCHEMBL2193917	C15H12ClN3O	285.731	2 / 1	2.7	Yes
522013	SCHEMBL2191655	C13H10ClN3O	259.693	2 / 1	2.5	Yes
522015	SCHEMBL2195676	C12H7F2N3O	247.205	4 / 1	1.7	Yes
522016	SCHEMBL2194167	C13H8F3N3OS	311.282	6 / 1	3.2	Yes
522322	SCHEMBL2193094	C13H11N3O	225.251	2 / 1	1.8	Yes
25466	3-hydroxy-5-(trifluoromethyl)benzoic Acid	C8H5F3O3	206.12	6 / 2	2.0	Yes
25519	CHEMBL3298700	C20H19NO3	321.376	3 / 2	4.3	Yes
522394	SCHEMBL2191732	C13H10ClN3O	259.693	2 / 1	2.8	Yes
522469	SCHEMBL2193674	C12H7Cl2N3O	280.108	2 / 1	2.7	Yes
522540	SCHEMBL2194109	C13H11N3O	225.251	2 / 1	1.8	Yes
522583	SCHEMBL2192923	C13H10BrN3O	304.147	2 / 1	2.5	Yes
522632	3-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-5-OL	C12H9N3O	211.224	2 / 1	1.5	Yes
41063	3-hydroxy-5-methylbenzoic acid	C8H8O3	152.149	3 / 2	1.5	Yes
522768	SCHEMBL2196115	C12H7Cl3N4O	329.565	3 / 2	3.0	Yes
522802	SCHEMBL2194756	C13H10ClN3O	259.693	2 / 1	2.4	Yes
523004	SCHEMBL2195290	C13H12N4O	240.266	3 / 2	1.5	Yes
523070	SCHEMBL2195804	C12H8BrN3O	290.12	2 / 1	2.1	Yes
523148	SCHEMBL2193614	C14H13N3O	239.278	2 / 1	2.2	Yes
523172	SCHEMBL2191146	C16H11N3O	261.284	2 / 1	2.7	Yes
523249	SCHEMBL2195380	C10H7N3OS	217.246	3 / 1	1.1	Yes
523488	SCHEMBL2193336	C13H8Cl3N3O	328.577	2 / 1	3.7	Yes
523637	SCHEMBL2191413	C16H12F3N3O2	335.286	6 / 1	3.2	Yes
523662	SCHEMBL2194913	C13H10BrN3O	304.147	2 / 1	2.5	Yes
523725	SCHEMBL2194452	C13H17N3O4S	311.356	5 / 1	1.7	Yes
523830	SCHEMBL2194383	C13H10BrN3O	304.147	2 / 1	2.5	Yes
523984	SCHEMBL2194051	C14H13N3OS	271.338	3 / 1	2.4	Yes
524041	SCHEMBL2192711	C12H14ClN3O	251.714	2 / 1	2.5	Yes
524250	SCHEMBL2193699	C13H7ClF3N3O2	329.663	6 / 1	3.6	Yes
524283	SCHEMBL2193535	C17H14N4O	290.326	3 / 2	2.7	Yes
524510	SCHEMBL2194776	C12H7ClFN3O	263.656	3 / 1	2.2	Yes
524550	SCHEMBL2192314	C12H8FN3O	229.214	3 / 1	1.6	Yes
524620	SCHEMBL2195780	C12H9BrN4O	305.135	3 / 2	1.8	Yes
524676	SCHEMBL2193920	C13H18N4O	246.314	3 / 2	1.7	Yes
524803	SCHEMBL2192056	C12H13N3O2	231.255	3 / 1	0.6	Yes
524885	SCHEMBL2193737	C17H24N4O3	332.404	4 / 1	1.5	Yes
524934	SCHEMBL2194779	C13H15N3O	229.283	2 / 1	1.4	Yes
524940	SCHEMBL2191868	C13H7ClF3N3OS	345.724	6 / 1	4.1	Yes
525034	SCHEMBL2194614	C13H7BrF3N3O	358.118	5 / 1	3.0	Yes
525035	SCHEMBL2191477	C12H8ClFN4O	278.671	4 / 2	1.8	Yes
525066	SCHEMBL2191383	C13H9N3O3	255.233	4 / 1	1.3	Yes
525207	SCHEMBL2192074	C17H13N3O	275.311	2 / 1	3.1	Yes
525222	SCHEMBL2195952	C11H13N3O	203.245	2 / 1	1.0	Yes
525350	SCHEMBL2193525	C11H13N3OS	235.305	3 / 1	0.9	Yes
132886	CHEMBL3299016	C19H17ClN2O3	356.806	4 / 2	4.3	Yes
134514	3-Hydroxybenzoic acid	C7H6O3	138.122	3 / 2	1.5	Yes
525418	CHEMBL3717311	C13H11FN4O	258.256	4 / 2	1.6	Yes
525424	SCHEMBL2194710	C13H10FN3O	243.241	3 / 1	1.9	Yes
525434	SCHEMBL2192915	C13H11N3O2	241.25	3 / 1	1.4	Yes
525460	SCHEMBL2192648	C17H12ClN3O	309.753	2 / 1	3.7	Yes
525484	SCHEMBL2193662	C13H17N3O	231.299	2 / 1	2.0	Yes
138446	CHEMBL3299014	C22H24N2O6	412.442	7 / 2	3.3	Yes
525558	SCHEMBL2195088	C12H7Br2N3O	369.016	2 / 1	3.2	Yes
525661	SCHEMBL2195362	C12H8F2N4O	262.22	5 / 2	1.3	Yes
525708	SCHEMBL2192372	C11H13N3O2	219.244	3 / 1	0.1	Yes
147498	CHEMBL3299011	C19H18N2O3	322.364	4 / 2	3.3	Yes
525852	SCHEMBL2195973	C13H10FN3O	243.241	3 / 1	2.0	Yes
525857	SCHEMBL2193205	C17H13N3O	275.311	2 / 1	3.1	Yes
525904	SCHEMBL2194396	C14H13N3O	239.278	2 / 1	2.2	Yes
554096	L-Lactic acid	C3H6O3	90.078	3 / 2	-0.7	Yes
554097	D-Lactic acid	C3H6O3	90.078	3 / 2	-0.7	Yes
164480	CHEMBL2146992	C7H9O4P	188.119	4 / 3	-0.3	Yes
526226	SCHEMBL2194841	C14H13N3O	239.278	2 / 1	2.2	Yes
526228	SCHEMBL2196066	C15H13N3O	251.289	2 / 1	2.3	Yes
526269	SCHEMBL2194807	C15H14N4O	266.304	3 / 2	1.9	Yes
526277	SCHEMBL2193009	C14H10F3N3OS	325.309	6 / 1	3.6	Yes
169465	CHEMBL3297873	C19H20N2O3	324.38	4 / 2	3.1	Yes
526362	SCHEMBL2191453	C13H11FN4O	258.256	4 / 2	1.6	Yes
526455	SCHEMBL2195250	C10H11N3O	189.218	2 / 1	0.6	Yes
526509	SCHEMBL2194878	C15H15N3O	253.305	2 / 1	2.6	Yes
526524	SCHEMBL2196891	C13H9BrClN3O	338.589	2 / 1	3.1	Yes
526533	SCHEMBL2194958	C12H7BrFN3O	308.11	3 / 1	2.6	Yes
526612	SCHEMBL2193083	C13H17N3O2	247.298	3 / 2	0.9	Yes
184401	CHEMBL3299116	C18H21NO5	331.368	5 / 2	3.0	Yes
526818	SCHEMBL2194695	C12H10N4O	226.239	3 / 2	1.1	Yes
526905	SCHEMBL2195073	C12H8FN3O	229.214	3 / 1	1.6	Yes
526919	SCHEMBL2194137	C12H6Cl3N3O	314.55	2 / 1	3.3	Yes
527043	SCHEMBL2194662	C13H8F3N3O2	295.221	6 / 1	2.6	Yes
527092	SCHEMBL2192444	C14H13N3O	239.278	2 / 1	2.2	Yes
527193	SCHEMBL2193900	C18H13N3O	287.322	2 / 1	3.1	Yes
196800	CHEMBL3299007	C21H21NO4	351.402	4 / 2	4.3	Yes
527269	SCHEMBL2194536	C13H10ClN3O	259.693	2 / 1	2.4	Yes
202091	CHEMBL3298703	C21H21NO3	335.403	3 / 2	4.1	Yes
527386	SCHEMBL2191538	C13H17N3O	231.299	2 / 1	1.9	Yes
527446	SCHEMBL2192519	C16H10ClN3O	295.726	2 / 1	3.3	Yes
527496	SCHEMBL2192302	C13H15F2N3O	267.28	4 / 1	2.2	Yes
210339	CHEMBL3297875	C20H21ClN2O4	388.848	5 / 2	4.1	Yes
527603	SCHEMBL2193932	C12H7Cl2N3O	280.108	2 / 1	2.7	Yes
527690	SCHEMBL2192271	C15H15N3O	253.305	2 / 1	2.6	Yes
527761	SCHEMBL2194142	C16H19N3O	269.348	2 / 1	2.4	Yes
527764	SCHEMBL2193630	C13H11N3OS	257.311	3 / 1	2.3	Yes
527856	SCHEMBL2193355	C12H9ClN4O	260.681	3 / 2	1.7	Yes
527862	SCHEMBL2192545	C13H11N3O	225.251	2 / 1	1.9	Yes

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417