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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Ligand

Name	5-Hydroxynicotinic acid
Molecular formula	C6H5NO3
IUPAC name	5-hydroxypyridine-3-carboxylic acid
Molecular weight	139.11
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.0
Synonyms	AK-25698 BBL010930 FC0319 J-400705 MFCD00129117 Oprea1_193943 3-Pyridinecarboxylic acid, 5-hydroxy- (9CI) SC-03080 5-hydroxynicotinicacid TR-012396 AB01334129-02 AM20051033 BDBM50391823 CTK1A2289 FT-0621168 KS-000006OW NCGC00342404-01 3-Carboxy-5-hydroxypyridine PubChem2415 5-hydroxy nicotinic acid ST50258394 5-hydroxypyridinium-3-carboxylate Z57124104 AC1L1QSR ACT02416 ATTDCVLRGFEHEO-UHFFFAOYSA-N BRN 0115847 EBD49093 HMS1671H22 LS20727 NSC606891 3-pyridinecarboxylic acid, 5-hydroxy RW1130 SY003082 828H713 AKOS000272822 BC206883 CHEMBL2146902 FT-0084614 Jsp005378 MolPort-000-004-346 PB33816 3-PYRIDINECARBOXYLIC ACID,5-HYDROXY- SCHEMBL186161 5-hydroxypyridine-3-carboxylic acid TRA0020186 AB1001515 ACMC-209gz9 AN-13577 BP-21442 DB-009085 H67204 KSC202E8T NICOTINIC ACID, 5-HYDROXY- 3-HYDROXY-5-PYRIDINECARBOXYLIC ACID RP01192 5-Hydroxy-3-pyridinecarboxylic acid STK531022 ZINC332673 AE-848/00984004 BAS 01947666 C-5668 EN300-73559 I02-0317 MCULE-4896018532 Oprea1_058796 3-Pyridinecarboxylic acid, 5-hydroxy- SBB010273 5-Hydroxynicotinic acid, 97% TPC-PY046 AB0006010 AKOS005463460 BCP27371 CS-W009148 FT-0602367 KB-32240 MolPort-000-712-122 27828-71-3 PS-5446 5-22-05-00113 (Beilstein Handbook Reference) ST24033026 5-hydroxypyridine-3-carboxylicacid TRA0035387 AC-2839 ACN-049106 ANW-26275 BR-25698 DTXSID50182143 HC150102 LS-96574 NSC-606891 3-Hydroxypyridine-5-carboxylic acid RTR-012396 5-Hydroxy-nicotinic acid STK801985 5HN [ Show all ]
Inchi Key	ATTDCVLRGFEHEO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H5NO3/c8-5-1-4(6(9)10)2-7-3-5/h1-3,8H,(H,9,10)
PubChem CID	34037
ChEMBL	CHEMBL2146902
IUPHAR	N/A
BindingDB	50391823
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID24900524	BindingDB,ChEMBL

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