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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Ligand

Name	SCHEMBL2193009
Molecular formula	C14H10F3N3OS
IUPAC name	2-methyl-3-[2-(trifluoromethylsulfanyl)phenyl]-4H-imidazo[4,5-b]pyridin-5-one
Molecular weight	325.309
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.6
Synonyms	CHEMBL3715889
Inchi Key	KFELIYWRFXZXNX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H10F3N3OS/c1-8-18-9-6-7-12(21)19-13(9)20(8)10-4-2-3-5-11(10)22-14(15,16)17/h2-7H,1H3,(H,19,21)
PubChem CID	58345765
ChEMBL	CHEMBL3715889
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14.0 nM	None	ChEMBL
EC50	230.0 nM	None	ChEMBL

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