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GPCR

NameHydroxycarboxylic acid receptor 1
SpeciesHomo sapiens (Human)
GeneHCAR1
Synonymlactate receptor 1
LACR1
HCA1 receptor
Gpr81
G-protein coupled receptor 81
[ Show all ]
DiseaseN/A
Length346
Amino acid sequenceMYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProtQ9BXC0
Protein Data BankN/A
GPCR-HGmod modelQ9BXC0
3D structure modelThis predicted structure model is from GPCR-EXP Q9BXC0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075101
IUPHAR311
DrugBankN/A

Ligand

NameSCHEMBL2191868
Molecular formulaC13H7ClF3N3OS
IUPAC name2-chloro-3-[2-(trifluoromethylsulfanyl)phenyl]-4H-imidazo[4,5-b]pyridin-5-one
Molecular weight345.724
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.1
SynonymsCHEMBL3715927
Inchi KeyHLUCMICIQGMDBP-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H7ClF3N3OS/c14-12-18-7-5-6-10(21)19-11(7)20(12)8-3-1-2-4-9(8)22-13(15,16)17/h1-6H,(H,19,21)
PubChem CID58345656
ChEMBLCHEMBL3715927
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5014.0 nMNoneChEMBL
EC50230.0 nMNoneChEMBL

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