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Name | Hydroxycarboxylic acid receptor 1 |
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Species | Homo sapiens (Human) |
Gene | HCAR1 |
Synonym | lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 [ Show all ] |
Disease | N/A |
Length | 346 |
Amino acid sequence | MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH |
UniProt | Q9BXC0 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9BXC0 |
3D structure model | This predicted structure model is from GPCR-EXP Q9BXC0. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075101 |
IUPHAR | 311 |
DrugBank | N/A |
Name | SCHEMBL2191868 |
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Molecular formula | C13H7ClF3N3OS |
IUPAC name | 2-chloro-3-[2-(trifluoromethylsulfanyl)phenyl]-4H-imidazo[4,5-b]pyridin-5-one |
Molecular weight | 345.724 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 4.1 |
Synonyms | CHEMBL3715927 |
Inchi Key | HLUCMICIQGMDBP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C13H7ClF3N3OS/c14-12-18-7-5-6-10(21)19-11(7)20(12)8-3-1-2-4-9(8)22-13(15,16)17/h1-6H,(H,19,21) |
PubChem CID | 58345656 |
ChEMBL | CHEMBL3715927 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 14.0 nM | None | ChEMBL |
EC50 | 230.0 nM | None | ChEMBL |
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