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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Ligand

Name	SCHEMBL2192302
Molecular formula	C13H15F2N3O
IUPAC name	3-(2,2-difluorocycloheptyl)-4H-imidazo[4,5-b]pyridin-5-one
Molecular weight	267.28
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.2
Synonyms	CHEMBL3716370 3-(2,2-Difluorocycloheptyl)-3H-imidazo[4,5-b]pyridin-5-ol MLQNPYLSTHCUPE-UHFFFAOYSA-N
Inchi Key	MLQNPYLSTHCUPE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15F2N3O/c14-13(15)7-3-1-2-4-10(13)18-8-16-9-5-6-11(19)17-12(9)18/h5-6,8,10H,1-4,7H2,(H,17,19)
PubChem CID	58345763
ChEMBL	CHEMBL3716370
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14.0 nM	None	ChEMBL
EC50	230.0 nM	None	ChEMBL

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