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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Ligand

Name	D-Lactic acid
Molecular formula	C3H6O3
IUPAC name	(2R)-2-hydroxypropanoic acid
Molecular weight	90.078
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-0.7
Synonyms	EINECS 233-713-2 (R)-Milchsaeure L-2-Hydroxypropanoic acid 1-Hydroxyethane 1-carboxylic acid Propanoic acid, 2-hydroxy-, a-Hydroxypropanoate UNII-3Q6M5SET7W alpha-Hydroxypropanoate bmse000269 D-( pound inverted question mark)-Lactic acid D-2-Hydroxypropionic acid DB03066 (D)-(-)-Lactic acid delta-Lactic acid (R)-2-Hydroxypropionic acid (R)-a-Hydroxypropionic acid HY-111095 (S)-2-hydroxy-Propanoate Lactic acid, D- 10326-41-7 Propel a-Hydroxypropionic acid ZINC4658562 AN-20389 CHEBI:42111 D-(-)-Lactic acid, >=90% D-Lactic acid, aq. soln., tech. (-)-Lactate delta-2-Hydroxypropanoate (R)-2-hydroxy-propionic acid DSSTox_GSID_47030 EBD2761138 (R)-lactate L-(+)-Lactate (S)-2-Hydroxypropionate NCGC00248189-01 32682-EP2311827A1 SC-20005 AJ-51842 B-6294 CTK8B4737 D-2-Hydroxypropanoic acid D-Milchsaure (alpha)-Lactate delta-2-Hydroxypropionic acid (R)-2-Hydroxypropanoic acid FT-0696525 (S)-(+)-2-Hydroxypropanoate L0266 1-Hydroxyethanecarboxylate Propanoic acid, 2-hydroxy-, (2R)- a-Hydroxypropanoic acid W-108854 alpha-Hydroxypropanoic acid C00256 D-(-)-Lactate D-lactate delta-(-)-Lactate (R)-(-)-Lactate DLA (R)-2-Hydroxypropionsaeure (R)-alpha-Hydroxypropionate JVTAAEKCZFNVCJ-UWTATZPHSA-N (S)-2-hydroxy-Propanoic acid MFCD00068311 PubChem16738 AC1L1VD8 ANW-45986 CHEMBL358850 D-2-Hydroxy propionic acid D-Lactic acid, aqueous solution, Techincal grade (-)-Lactic acid delta-2-Hydroxypropanoic acid (R)-2-Hydroxy-propionic acid;H-D-Lac-OH DSSTox_RID_82051 EC 233-713-2 (R)-Lactic acid L-2-Hydroxypropanoate 1-Hydroxyethane 1-carboxylate NCGC00254746-01 3Q6M5SET7W Tox21_300843 AKOS006345747 BDBM50420196 D(-)-lactic acid D-2-hydroxypropionate D0DA9T (alpha)-Lactic acid delta-Lactate (R)-2-Hydroxypropionate GTPL2934 (S)-(+)-2-Hydroxypropanoic acid Lactic acid (D) 1-Lactic acid Propanoic acid, 2-hydroxy-, (R)- a-Hydroxypropionate X8654 alpha-Hydroxypropionate CAS-10326-41-7 D-(-)-Lactic acid (+)-Lactate delta-(-)-Lactic acid (R)-(-)-Lactic acid DSSTox_CID_27030 (R)-a-Hydroxypropionate (R)-alpha-Hydroxypropionic acid l-(+)- lactic acid (S)-2-Hydroxypropanoate MolPort-003-936-000 32682-EP2301933A1 R-lactic acid ACT03143 AS-19478 CS-0034207 D-2-hydroxypropanoate D-Milchsaeure (2R)-2-hydroxypropanoic acid delta-2-Hydroxypropionate (R)-2-Hydroxypropanoate DTXSID0047030 [ Show all ]
Inchi Key	JVTAAEKCZFNVCJ-UWTATZPHSA-N
Inchi ID	InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
PubChem CID	61503
ChEMBL	N/A
IUPHAR	2934
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3019950.0 nM	PMID18952058	IUPHAR

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