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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Ligand

Name	SCHEMBL2193917
Molecular formula	C15H12ClN3O
IUPAC name	3-(2-chlorophenyl)-2-cyclopropyl-4H-imidazo[4,5-b]pyridin-5-one
Molecular weight	285.731
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	CHEMBL3714879
Inchi Key	AXGGHPMVSGFWGC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H12ClN3O/c16-10-3-1-2-4-12(10)19-14(9-5-6-9)17-11-7-8-13(20)18-15(11)19/h1-4,7-9H,5-6H2,(H,18,20)
PubChem CID	58345768
ChEMBL	CHEMBL3714879
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14.0 nM	None	ChEMBL
EC50	230.0 nM	None	ChEMBL

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