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| Name | Thromboxane A2 receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | TBXA2R |
| Synonym | TP receptor TXA2-R prostanoid TP receptor |
| Disease | Diabetic neuropathy Cardiovascular disorder Erectile dysfunction Perennial allergic rhinitis Peripheral vascular disease [ Show all ] |
| Length | 343 |
| Amino acid sequence | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ |
| UniProt | P21731 |
| Protein Data Bank | 6iiv, 6iiu |
| GPCR-HGmod model | P21731 |
| 3D structure model | This structure is from PDB ID 6iiv. |
| BioLiP | BL0436518, BL0436517, BL0436516, BL0436515, BL0436514, BL0436513 |
| Therapeutic Target Database | T76198 |
| ChEMBL | CHEMBL2069 |
| IUPHAR | 346 |
| DrugBank | BE0000759 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 595 |  CHEMBL340073 | C17H24NO4S- | 338.442 | 5 / 1 | 3.5 | Yes |
| 833 |  CHEMBL309835 | C26H29NO5S | 467.58 | 6 / 2 | 5.4 | No |
| 1523 |  CHEMBL1088284 | C25H17F3N2O2 | 434.418 | 7 / 1 | 5.0 | Yes |
| 1592 |  CHEMBL207203 | C23H24ClNO5S | 461.957 | 5 / 2 | 3.0 | Yes |
| 1600 |  CHEMBL378744 | C23H24ClNO5S | 461.957 | 5 / 2 | 3.0 | Yes |
| 1662 |  CHEMBL2402575 | C17H16ClN3O4S | 393.842 | 5 / 2 | 3.2 | Yes |
| 1706 |  CHEMBL379736 | C19H30N4O5S | 426.532 | 6 / 3 | 5.0 | Yes |
| 1825 |  CHEMBL314533 | C38H34N2O4S | 614.76 | 4 / 1 | 7.6 | No |
| 3504 |  CHEMBL206631 | C21H20ClNO2 | 353.846 | 2 / 1 | 4.7 | Yes |
| 3554 |  CHEMBL117821 | C31H24N2O4 | 488.543 | 5 / 2 | 4.8 | Yes |
| 3642 |  CHEMBL277167 | C23H28N2O7S | 476.544 | 9 / 1 | 3.9 | Yes |
| 3784 |  CHEMBL126337 | C26H27ClN2O4S | 499.022 | 6 / 1 | 5.4 | No |
| 3820 |  CHEMBL282601 | C30H42N2O4 | 494.676 | 5 / 2 | 6.4 | No |
| 4077 |  CHEMBL108289 | C24H21ClN2O2 | 404.894 | 3 / 0 | 5.8 | No |
| 4105 |  CHEMBL122008 | C23H24FN3O3 | 409.461 | 6 / 1 | 4.4 | Yes |
| 4106 |  CHEMBL118188 | C23H24FN3O3 | 409.461 | 6 / 1 | 4.4 | Yes |
| 4551 |  CHEMBL430124 | C20H27NO4S | 377.499 | 5 / 2 | 2.4 | Yes |
| 4615 |  CHEMBL269457 | C25H29ClFNO6S | 526.016 | 8 / 2 | 4.4 | No |
| 4712 |  CHEMBL158576 | C33H46N2O4 | 534.741 | 6 / 1 | 3.8 | No |
| 5135 |  CHEMBL65121 | C17H18ClNO4S | 367.844 | 5 / 2 | 3.2 | Yes |
| 5359 |  CHEMBL99041 | C23H25N3O4 | 407.47 | 5 / 3 | 2.8 | Yes |
| 5412 |  CHEMBL245261 | C18H21N3O7S | 423.44 | 7 / 2 | 2.8 | Yes |
| 5568 |  CHEMBL280396 | C19H27NO5S | 381.487 | 6 / 3 | 2.5 | Yes |
| 5569 |  CHEMBL19540 | C19H27NO5S | 381.487 | 6 / 3 | 2.5 | Yes |
| 6016 |  CHEMBL420678 | C26H22N2O3 | 410.473 | 4 / 1 | 4.7 | Yes |
| 6530 |  CHEMBL1290298 | C23H24FNO4S | 429.506 | 5 / 1 | 3.9 | Yes |
| 6634 |  CHEMBL177760 | C20H34O3S | 354.549 | 4 / 1 | 4.9 | Yes |
| 6761 |  CHEMBL380274 | C18H21N3O5S2 | 423.502 | 6 / 2 | 3.7 | Yes |
| 6891 |  CHEMBL182367 | C25H16ClF6NO2S | 543.908 | 10 / 1 | 7.1 | No |
| 7917 |  CHEMBL2093006 | C23H28N6O3 | 436.516 | 7 / 3 | 3.7 | Yes |
| 7918 |  CHEMBL22023 | C23H28N6O3 | 436.516 | 7 / 3 | 3.7 | Yes |
| 8379 |  CHEMBL395079 | C18H21N3O6S | 407.441 | 6 / 2 | 3.2 | Yes |
| 536213 |  SCHEMBL5208850 | C21H29ClO3 | 364.91 | 3 / 2 | 5.1 | No |
| 536223 |  SCHEMBL5205658 | C27H39ClO4 | 463.055 | 4 / 2 | 5.5 | No |
| 9252 |  CHEMBL2402427 | C20H23N3O4S | 401.481 | 5 / 2 | 3.9 | Yes |
| 553295 |  [125I]SQ-29548 | C21H28IN3O4 | 511.377 | 5 / 4 | 0.9 | No |
| 9393 |  CHEMBL189694 | C28H28O5S | 476.587 | 6 / 2 | 5.9 | No |
| 9850 |  CHEMBL520480 | C20H18Cl2N2O4S2 | 485.394 | 6 / 1 | 3.8 | Yes |
| 10430 |  CHEMBL274749 | C17H14ClFN2O2 | 332.759 | 4 / 1 | 3.6 | Yes |
| 10580 |  CHEMBL268048 | C26H30FNO5S | 487.586 | 7 / 2 | 4.3 | Yes |
| 10847 |  CHEMBL18421 | C20H21FN2O2 | 340.398 | 4 / 1 | 4.1 | Yes |
| 557602 |  CHEMBL172042 | C18H20N2O5 | 344.367 | 6 / 3 | 1.9 | Yes |
| 11121 |  CHEMBL30727 | C25H32N2O6 | 456.539 | 7 / 3 | 2.6 | Yes |
| 11199 |  CHEMBL1778505 | C23H24N2O3 | 376.456 | 3 / 1 | 3.0 | Yes |
| 11765 |  CHEMBL114213 | C26H22N2O5 | 442.471 | 6 / 1 | 3.9 | Yes |
| 12013 |  CHEMBL147444 | C32H41N3O4 | 531.697 | 5 / 3 | 7.3 | No |
| 13034 |  CHEMBL275382 | C20H21BrN2O2 | 401.304 | 3 / 1 | 4.7 | Yes |
| 13073 |  CHEMBL2402434 | C18H20N4O3S | 372.443 | 5 / 3 | 3.5 | Yes |
| 13141 |  CHEMBL275245 | C23H33NO5 | 403.519 | 5 / 2 | 2.2 | Yes |
| 13268 |  CHEMBL338420 | C26H25FN2O4S | 480.554 | 7 / 2 | 4.6 | Yes |
| 14306 |  CHEMBL60710 | C26H27N3O4 | 445.519 | 6 / 2 | 4.5 | Yes |
| 14365 |  CHEMBL336548 | C18H18F3N3O3 | 381.355 | 9 / 1 | 3.2 | Yes |
| 14366 |  CHEMBL435412 | C18H18F3N3O3 | 381.355 | 9 / 1 | 3.2 | Yes |
| 14574 |  CHEMBL208153 | C20H26N4O5S | 434.511 | 6 / 3 | 4.9 | Yes |
| 14608 |  CHEMBL131497 | C22H20NO4S- | 394.465 | 5 / 1 | 4.5 | Yes |
| 15254 |  CHEMBL65161 | C29H31NO3S | 473.631 | 5 / 1 | 5.5 | No |
| 442245 |  [(5Z,8R,9S,11R,12R,13E,15S)-9,11,15-Trihydroxy-1-norprosta-5,13-diene-2-yl]phosphinic acid | C19H35O5P | 374.458 | 5 / 4 | 1.9 | Yes |
| 15400 |  CHEMBL17673 | C18H16ClFN2O2S | 378.846 | 5 / 1 | 4.5 | Yes |
| 15409 |  CHEMBL1290299 | C23H23ClFNO4S | 463.948 | 5 / 1 | 4.5 | Yes |
| 16332 |  CHEMBL90491 | C37H32N2O4S | 600.733 | 4 / 1 | 7.3 | No |
| 16403 |  CHEMBL10639 | C31H32FNO5S | 549.657 | 7 / 2 | 5.4 | No |
| 16709 |  CHEMBL264740 | C26H38N2O5S | 490.659 | 7 / 2 | 5.2 | No |
| 16801 |  Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
| 16824 |  CHEMBL410732 | C28H30N2O5 | 474.557 | 6 / 2 | 4.2 | Yes |
| 442357 |  CHEMBL21392 | C25H30N4O4 | 450.539 | 7 / 3 | 6.6 | No |
| 18084 |  CHEMBL474502 | C20H18Cl2N2O4S2 | 485.394 | 6 / 1 | 3.8 | Yes |
| 18360 |  CHEMBL207805 | C22H19ClN2O4S | 442.914 | 5 / 1 | 3.2 | Yes |
| 19205 |  CHEMBL1643775 | C22H20F4N2O4S | 484.466 | 9 / 1 | 3.7 | Yes |
| 19361 |  CHEMBL114751 | C24H22N2O4S | 434.51 | 5 / 3 | 3.8 | Yes |
| 553337 |  Ifetroban | C25H32N2O5 | 440.54 | 6 / 2 | 4.0 | Yes |
| 19729 |  CHEMBL283100 | C25H32N2O5 | 440.54 | 6 / 2 | 4.0 | Yes |
| 19747 |  CHEMBL159517 | C32H44N2O4 | 520.714 | 6 / 1 | 3.2 | No |
| 20100 |  CHEMBL17463 | C21H23ClN2O4S | 434.935 | 5 / 1 | 3.9 | Yes |
| 20130 |  CHEMBL207104 | C21H20ClNO4S | 417.904 | 4 / 1 | 3.4 | Yes |
| 20137 |  CHEMBL159581 | C31H40N2O5 | 520.67 | 6 / 2 | 1.8 | No |
| 20684 |  CHEMBL330837 | C18H23N3O3 | 329.4 | 5 / 1 | 2.7 | Yes |
| 20842 |  CHEMBL518988 | C22H22Cl2N2O2S | 449.39 | 4 / 1 | 5.4 | No |
| 21347 |  CHEMBL108856 | C24H19ClN4OS | 446.953 | 5 / 0 | 6.3 | No |
| 21695 |  CHEMBL116836 | C25H30FNO3S | 443.577 | 5 / 2 | 5.7 | No |
| 21722 |  CHEMBL1643772 | C22H23FN2O6S2 | 494.552 | 8 / 1 | 2.1 | Yes |
| 21804 |  CHEMBL406649 | C21H17F4NO4S2 | 487.484 | 9 / 1 | 3.9 | Yes |
| 22142 |  CHEMBL283374 | C26H28ClF3N2O5S | 573.024 | 10 / 2 | 5.5 | No |
| 22194 |  CHEMBL62977 | C25H29NO4 | 407.51 | 5 / 2 | 3.8 | Yes |
| 22196 |  CHEMBL60613 | C25H29NO4 | 407.51 | 5 / 2 | 3.8 | Yes |
| 536551 |  CHEMBL3896035 | C27H36F4N4O5S | 604.662 | 11 / 2 | 5.6 | No |
| 22806 |  CHEMBL601299 | C20H14Cl3NO3S | 454.746 | 4 / 2 | 6.4 | No |
| 23281 |  CHEMBL161532 | C31H42N2O5 | 522.686 | 7 / 2 | 1.5 | No |
| 23484 |  CHEMBL1641809 | C20H19ClFN3O4S | 451.897 | 7 / 1 | 3.1 | Yes |
| 23836 |  TMQ, 5-TrifluoroMe | C20H22F3NO5 | 413.393 | 9 / 3 | 3.4 | Yes |
| 24092 |  CHEMBL338546 | C20H23ClN2O4S | 422.924 | 6 / 2 | 3.8 | Yes |
| 24676 |  CHEMBL110063 | C22H18ClN3O2 | 391.855 | 4 / 1 | 5.4 | No |
| 24717 |  CHEMBL2402429 | C19H22N4O3S | 386.47 | 5 / 3 | 3.7 | Yes |
| 536649 |  SCHEMBL671511 | C29H38F4N4O5S | 630.7 | 11 / 2 | 6.2 | No |
| 536676 |  SCHEMBL1309617 | C21H25NO4S | 387.494 | 5 / 1 | 4.0 | Yes |
| 26348 |  CHEMBL334501 | C20H21ClNNaO4S | 429.891 | 5 / 1 | N/A | N/A |
| 26409 |  CHEMBL207201 | C24H20BrClN2O4S | 547.848 | 5 / 1 | 4.4 | No |
| 27094 |  CHEMBL21204 | C18H24FNO5S | 385.45 | 7 / 2 | 2.3 | Yes |
| 27111 |  CHEMBL1641817 | C26H28FN3O3 | 449.526 | 5 / 1 | 3.8 | Yes |
| 27219 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27578 |  CHEMBL77097 | C25H29NO5S | 455.569 | 6 / 2 | 5.2 | No |
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