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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	LE 300
Molecular formula	C20H22N2
IUPAC name	11-methyl-11,21-diazatetracyclo[12.7.0.03,8.015,20]henicosa-1(14),3,5,7,15,17,19-heptaene
Molecular weight	290.41
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	4.3
Synonyms	B6824 CHEMBL441618 HMS3372E16 LP00699 NCGC00025255-01 SR-01000075963-1 7-methyl-6,7,8,9,14,15-hexahydro-5H-benzo[7,8]azecino[5,4-b]indole(LE 300) 7-methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]benzazecine BRD-K01648091-001-01-8 DTXSID20402244 NCGC00015614-01 NCGC00261384-01 Tox21_500699 11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene AKOS024456742 CHEBI:92030 HMS3262K19 Lopac-L-8401 NCGC00015614-04 SMR001230741 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine BDBM50088341 CTK8E8452 J-016773 MLS002153328 NCGC00025255-02 SR-01000075963-3 AC1N8VWD BRD-K01648091-001-04-2 EU-0100699 LE 300, solid NCGC00015614-02 RT-013566 ZINC1486281 274694-98-3 API0008482 HMS3268M15 Lopac0_000699 NCGC00015614-05 SR-01000075963 6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f][3]benzazecine 7-Methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]-benzazecine BN0302 D07YLK L 8401 MolPort-003-958-572 NCGC00025255-03 Tocris-1674 ACM274694983 CCG-204784 HMS2233O19 LE-300 NCGC00015614-03 SCHEMBL12610513 3-Methyl-1,2,3,4,5,8-hexahydro-(14,15-[1,4]butanediylidene-(7,6-(iminoethano)-3-benzoazecine))-17-ene [ Show all ]
Inchi Key	YEWGIGCYIAMFMA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
PubChem CID	4350931
ChEMBL	CHEMBL441618
IUPHAR	N/A
BindingDB	50088341
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
408438	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
408439	5-hydroxytryptamine receptor 2A	P50129	HTR2A	Sus scrofa (Pig)	470
408447	Adenosine receptor A1	P30542	ADORA1	Homo sapiens (Human)	326
408440	D(1A) dopamine receptor	Q61616	Drd1	Mus musculus (Mouse)	446
408441	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
408445	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
408436	D(1B) dopamine receptor	P21918	DRD5	Homo sapiens (Human)	477
408442	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
408444	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
408435	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
408446	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
408437	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
408443	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460

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